CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
让我们精确地开启和关闭 CAR-T 细胞
英文原题：Let's turn the CAR-T cells ON and OFF precisely.
查看英文原题
Let's turn the CAR-T cells ON and OFF precisely.
分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。
中文摘要
在本期Cancer Cell中，Li等人基于病毒NS3蛋白酶系统，利用临床获批药物开发了新型可调控的ON/OFF开关嵌合抗原受体（CAR）回路。这些平台不仅展现出优越的可控性，还具有高性能和兼容性，从而为精确调控CAR-T 细胞提供了多功能工具。
展开英文摘要原文
In this issue of Cancer Cell, Li et al. develop novel tunable ON/OFF switch chimeric antigen receptor (CAR) circuits using clinically approved drugs based on the viral NS3 protease system. These platforms not only show superior controllability but also have high performance and compatibility, thereby providing versatile tools for precisely modulating CAR-T cells.
论文信息
- 作者
- Zhang J、Du B、Liu M
- 第一作者单位
- Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China. Electronic address: zjqjeremy@163.com.China
- 通讯作者单位
- Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China. Electronic address: myliu@bio.ecnu.edu.cn.China
- 文献类型
- 评论
- 期刊
- Cancer cell2022 Nov 14
- 原文标识
- PubMed 36379203 · DOI 10.1016/j.ccell.2022.10.019