CD81 通过阻断 CD274/PD-L1 的选择性自噬降解驱动放射抵抗性胶质母细胞瘤的免疫逃逸
CD81 drives immune evasion in radioresistant glioblastoma by blocking selective autophagic degradation of CD274/PD-L1.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
多形性胶质母细胞瘤免疫治疗的进展
英文原题：Advances in immunotherapy for glioblastoma multiforme.
查看英文原题
Advances in immunotherapy for glioblastoma multiforme.
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中文摘要
多形性胶质母细胞瘤（GBM）是中枢神经系统最常见、侵袭性最强的恶性脑肿瘤，预后极差。目前GBM标准治疗包括手术切除、放疗和化疗。不幸的是，传统疗法并未显著改善患者生存结局，因此总体死亡率仍然很高。免疫治疗通过帮助免疫系统对抗癌症发挥作用，并已在多种侵袭性癌症中取得成功。近年来，医疗领域积极研究多种治疗GBM的免疫疗法。本文综述了在临床试验中取得令人鼓舞结果、最具前景的胶质母细胞瘤免疫治疗候选方案，重点介绍免疫检查点抑制剂、溶瘤病毒、非复制型病毒载体以及嵌合抗原受体（CAR）免疫疗法。
展开英文摘要原文
Glioblastoma multiforme (GBM) is the most common and aggressive malignant brain tumor of the central nervous system and has a very poor prognosis. The current standard of care for patients with GBM involves surgical resection, radiotherapy, and chemotherapy. Unfortunately, conventional therapies have not resulted in significant improvements in the survival outcomes of patients with GBM; therefore, the overall mortality rate remains high.
Immunotherapy is a type of cancer treatment that helps the immune system to fight cancer and has shown success in different types of aggressive cancers. Recently, healthcare providers have been actively investigating various immunotherapeutic approaches to treat GBM.
We reviewed the most promising immunotherapy candidates for glioblastoma that have achieved encouraging results in clinical trials, focusing on immune checkpoint inhibitors, oncolytic viruses, nonreplicating viral vectors, and chimeric antigen receptor (CAR) immunotherapies.
论文信息
- 作者
- Mahmoud AB、Ajina R、Aref S、Darwish M、Alsayb M、Taher M、AlSharif SA、Hashem AM
- 第一作者单位
- College of Applied Medical Sciences, Taibah University, Almadinah Almunwarah, Saudi Arabia.Saudi Arabia
- 通讯作者单位
- Department of Medical Laboratory Technology, University of Tabuk, Tabuk, Saudi Arabia.Saudi Arabia
- 文献类型
- 综述
- 期刊
- Frontiers in immunology2022
- 原文标识
- PubMed 36311781 · DOI 10.3389/fimmu.2022.944452
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