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CAR-T 细胞治疗的诊疗一体化方法

英文原题:A Theranostic Approach for CAR-T Cell Therapy.

查看英文原题

A Theranostic Approach for CAR-T Cell Therapy.

PubMed 2022/12/15(内容时间) Clin Cancer Res Q1 · IF 10.9(JCR 2025)

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中文摘要

成纤维细胞活化蛋白(FAP)常在肿瘤间质中表达,而正常器官中的表达高度受限。尽管具有这些令人期待的特征,FAP靶向治疗迄今取得的成功有限。FAP成像为筛选适合FAP靶向治疗的患者和监测肿瘤反应提供了新机会。参见Lee等人的相关文章,第5330页。

展开英文摘要原文

Fibroblast activation protein (FAP) is frequently expressed in the tumor stroma, whereas expression by normal organs is highly restricted. Despite these promising features, FAP-targeted therapies have shown limited success so far. FAP imaging offers new opportunities to select patients for FAP-targeted therapies and monitor tumor response. See related article by Lee et al., p. 5330.

论文信息

作者
Weber WA、Varasteh Z、Fritschle K、Morath V
单位
Department of Nuclear Medicine, Technical University of Munich, Munich, Germany.Germany
文献类型
社论 · 非美国政府资助研究 · 评论
期刊
Clinical cancer research : an official journal of the American Association for Cancer Research2022 Dec 15
原文标识
PubMed 36250927 · DOI 10.1158/1078-0432.CCR-22-2565