CAR-T(CAR-T)细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T(CAR-T)细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题:A Theranostic Approach for CAR-T Cell Therapy.
A Theranostic Approach for CAR-T Cell Therapy.
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成纤维细胞活化蛋白(FAP)常在肿瘤间质中表达,而正常器官中的表达高度受限。尽管具有这些令人期待的特征,FAP靶向治疗迄今取得的成功有限。FAP成像为筛选适合FAP靶向治疗的患者和监测肿瘤反应提供了新机会。参见Lee等人的相关文章,第5330页。
Fibroblast activation protein (FAP) is frequently expressed in the tumor stroma, whereas expression by normal organs is highly restricted. Despite these promising features, FAP-targeted therapies have shown limited success so far. FAP imaging offers new opportunities to select patients for FAP-targeted therapies and monitor tumor response. See related article by Lee et al., p. 5330.
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