免疫检查点阻断通过扩增效应 CD8⁺ T 细胞克隆增强淋巴细胞清除性化疗诱导的抗肿瘤免疫
Immune Checkpoint Blockade Augments Lymphodepleting Chemotherapy-Induced Antitumor Immunity by Expanding Effector CD8+ T-cell Clones.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
实体癌的下一代 T 细胞疗法
英文原题：Next generation T cell therapies for solid cancers.
查看英文原题
Next generation T cell therapies for solid cancers.
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中文摘要
TIL（肿瘤浸润淋巴细胞）在转移性黑色素瘤中显示出持续的临床获益，但其产品定义不明确且抗肿瘤活性多变。在本期，Palmer等人1通过敲除CISH——一种T细胞活化抑制剂——构建了一种由高功能肿瘤反应性T细胞组成的细胞产品用于临床测试。
展开英文摘要原文
Tumor-infiltrating lymphocytes show consistent clinical benefit in metastatic melanoma, but they are a poorly defined product with variable antitumor activity. In this issue, Palmer et al. 1 create for clinical testing a cell product consisting of highly functional tumor-reactive T cells by knocking out CISH, an inhibitor of T cell activation.
论文信息
- 作者
- Haanen JB、Schumacher TN
- 单位
- Division of Medical Oncology, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands; Division of Molecular Oncology and Immunology, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands; Department of Clinical Oncology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands. Electronic address: j.haanen@nki.nl.Netherlands
- 文献类型
- 评论
- 期刊
- Med (New York, N.Y.)2022 Oct 14
- 原文标识
- PubMed 36242997 · DOI 10.1016/j.medj.2022.09.008