RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
下一代免疫肿瘤学策略：释放 NK 细胞活性
英文原题：Next Generation Immuno-Oncology Strategies: Unleashing NK Cells Activity.
查看英文原题
Next Generation Immuno-Oncology Strategies: Unleashing NK Cells Activity.
分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。
中文摘要
近年来，免疫治疗已成为对抗多种恶性肿瘤的有力治疗选择。自然杀伤（NK）细胞无需抗原特异性即可攻击癌细胞的独特能力，使其成为靶向肿瘤的最佳免疫治疗工具。目前临床上正在探索多种策略以最大化NK细胞的抗肿瘤特性，包括开发用于过继转移的NK细胞扩增方案、建立有利于NK细胞活性的微环境、重定向NK细胞对肿瘤细胞的活性，以及阻断限制NK细胞功能的抑制性机制。我们在此总结基于NK细胞免疫治疗的最新策略，并讨论进一步优化这些方法以提高靶向肿瘤的NK细胞免疫治疗临床疗效的必要性。
展开英文摘要原文
In recent years, immunotherapy has become a powerful therapeutic option against multiple malignancies. The unique capacity of natural killer (NK) cells to attack cancer cells without antigen specificity makes them an optimal immunotherapeutic tool for targeting tumors.
Several approaches are currently being pursued to maximize the anti-tumor properties of NK cells in the clinic, including the development of NK cell expansion protocols for adoptive transfer, the establishment of a favorable microenvironment for NK cell activity, the redirection of NK cell activity against tumor cells, and the blockage of inhibitory mechanisms that constrain NK cell function.
We here summarize the recent strategies in NK cell-based immunotherapies and discuss the requirement to further optimize these approaches for enhancement of the clinical outcome of NK cell-based immunotherapy targeting tumors.
论文信息
- 作者
- Mendoza-Valderrey A、Alvarez M、De Maria A、Margolin K、Melero I、Ascierto ML
- 单位
- Rosalie and Harold Rae Brown Cancer Immunotherapy Research Program, Borstein Family Melanoma Program, Translational Immunology Department, Saint John's Cancer Institute, Santa Monica, CA 90404, USA.United States
- 文献类型
- 综述 · 非美国政府资助研究
- 期刊
- Cells2022 Oct 6
- 原文标识
- PubMed 36231109 · DOI 10.3390/cells11193147
在 PubMed 查看 → 出版商原文（DOI） 全文 PDF（PMC）· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →