RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
转录延伸因子 A（SII）样（TCEAL）基因家族成员-TCEAL2：泛癌中的一种新型预后标志物
英文原题：Transcription Elongation Factor A (SII)-Like (TCEAL) Gene Family Member-TCEAL2: A Novel Prognostic Marker in Pan-Cancer.
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Transcription Elongation Factor A (SII)-Like (TCEAL) Gene Family Member-TCEAL2: A Novel Prognostic Marker in Pan-Cancer.
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研究概要
TCEAL2 可能是一种在不同癌症中的新型预后标志物，并可能通过免疫浸润影响肿瘤。
研究思路结论见上方概要
背景
癌症是世界范围内的主要死亡原因。其机制尚未完全阐明，治疗效果也不尽如人意。在我们的研究中，我们旨在寻找泛癌中的新靶基因。
方法
从GEO数据库中筛选出多种癌症中的差异表达基因（DEGs）。计算DEG（TCEAL2）在肿瘤细胞系、正常组织和肿瘤组织中的表达。然后研究TCEAL2的临床特征、DNA甲基化、肿瘤浸润和基因富集。
结果
TCEAL2在大多数癌症中表达下调。其表达和甲基化在不同癌症中与预后呈正相关或负相关。肿瘤浸润结果显示，TCEAL2在大多数癌症中与许多免疫细胞尤其是NK细胞及免疫相关基因显著相关。此外，tau蛋白和微管蛋白结合参与了TCEAL2的分子功能机制。
展开英文摘要原文
BACKGROUND
Cancer is the leading cause of death in the world. The mechanism is not fully elucidated and the therapeutic effect is also unsatisfactory. In our study, we aim to find new target gene in pan-cancer.
METHODS
Differently expressed genes (DEGs) was screened out in various types of cancers from GEO database. The expression of DEG (TCEAL2) in tumor cell lines, normal tissues and tumor tissues was calculated. Then the clinical characteristics, DNA methylation, tumor infiltration and gene enrichment of TCEAL2 was studied.
RESULTS
TCEAL2 expressions were down-regulated in most cancers. Its expression and methylation were positively or negatively associated with prognosis in different cancers. The tumor infiltration results revealed that TCEAL2 was significantly related with many immune cells especially NK cells and immune-related genes in majority cancers. Furthermore, tau protein and tubulin binding were involved in the molecular function mechanisms of TCEAL2.
CONCLUSION
TCEAL2 may be a novel prognostic marker in different cancers and may affect tumor through immune infiltration.
论文信息
- 作者
- Sun Y、Zhao J
- 单位
- Department of Nuclear Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.China
- 期刊
- Cancer informatics2022
- 原文标识
- PubMed 36199541 · DOI 10.1177/11769351221126285
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