RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
肿瘤微环境及其对胆管癌抗肿瘤免疫的影响：新型疗法的未来展望
英文原题：Tumor Microenvironment and its Implications for Antitumor Immunity in Cholangiocarcinoma: Future Perspectives for Novel Therapies.
查看英文原题
Tumor Microenvironment and its Implications for Antitumor Immunity in Cholangiocarcinoma: Future Perspectives for Novel Therapies.
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中文摘要
胆管癌（CCA）的发病率在过去几年中呈上升趋势。尽管存在手术、化疗等常规治疗方法，但效果并不理想。目前，免疫治疗已成为癌症治疗的研究前沿，而CCA肿瘤微环境（TME）正成为免疫生物学探索的热点方向。TME可通过代谢、分泌和免疫的变化影响肿瘤进展。因此，了解免疫细胞和基质细胞在TME中所发挥的作用对于CCA免疫治疗的研究至关重要。本综述将讨论CCA的TME中免疫细胞（包括CD8+ T细胞、CD4+ T细胞、巨噬细胞、NK 细胞、树突状细胞、髓系抑制细胞、肥大细胞和中性粒细胞）与基质细胞（包括癌症相关成纤维细胞、内皮细胞）之间的相互作用。此外，我们还将讨论目前关于CCA TME的研究成果以及免疫治疗的最新进展。
展开英文摘要原文
The incidence of cholangiocarcinoma (CCA) has been increasing over the past few years. Although there are surgery, chemotherapy and other conventional treatment methods, the effect is not as expected. At present, immunotherapy has become the research frontier of cancer treatment, and CCA tumor microenvironment (TME) is becoming a hot exploration direction of immunobiology. TME can affect tumor progression through changes in metabolism, secretion and immunity.
Accordingly, understanding the role played by immune cells and stromal cells in TME is important for the study of CCA immunotherapy. This review will discuss the interactions between immune cells (including CD8 + T cells, CD4 + T cells, macrophages, natural killer cells, dendritic cells, myeloid suppressor cells, mast cells, and neutrophils) and stromal cells (including cancer-associated fibroblasts, endothelial cells) in the TME of CCA.
In addition, we will also discuss current research results on TME of CCA and recent advances in immunotherapy.
论文信息
- 作者
- Cao H、Huang T、Dai M、Kong X、Liu H、Zheng Z、Sun G、Sun G
- 单位
- Hepatobiliary/Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Living Donor Transplantation, Chinese Academy of Medical Sciences, Nanjing, Jiangsu, China.China
- 文献类型
- 综述 · 非美国政府资助研究
- 期刊
- International journal of biological sciences2022
- 原文标识
- PubMed 36147461 · DOI 10.7150/ijbs.73949
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