CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
牛痘病毒用于肿瘤病毒治疗的设计策略与注意事项
英文原题：Design Strategies and Precautions for Using Vaccinia Virus in Tumor Virotherapy.
查看英文原题
Design Strategies and Precautions for Using Vaccinia Virus in Tumor Virotherapy.
分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。
中文摘要
溶瘤病毒疗法已成为一种新型的癌症免疫治疗形式。溶瘤病毒（OVs）能够直接感染并裂解肿瘤细胞，并调节有益的免疫微环境。痘苗病毒（VACV）因其高安全性、易于基因编辑和肿瘤内在选择性，成为一种有前景的溶瘤载体。为进一步提高安全性、肿瘤靶向能力以及OV诱导的癌症特异性免疫激活，多种方法已被用于改造OVs。删除病毒毒力因子和/或武装各种治疗基因的重组溶瘤VACVs在多种肿瘤模型中显示出更好的治疗效果。此外，OVs与其他癌症免疫治疗方法的联合，如免疫检查点抑制剂和CAR-T 细胞，有潜力改善癌症患者的预后。这将为OVs在癌症治疗中的应用开辟新的可能性，尤其是对于个性化癌症治疗。
展开英文摘要原文
Oncolytic virotherapy has emerged as a novel form of cancer immunotherapy. Oncolytic viruses (OVs) can directly infect and lyse the tumor cells, and modulate the beneficial immune microenvironment. Vaccinia virus (VACV) is a promising oncolytic vector because of its high safety, easy gene editing, and tumor intrinsic selectivity.
To further improve the safety, tumor-targeting ability, and OV-induced cancer-specific immune activation, various approaches have been used to modify OVs. The recombinant oncolytic VACVs with deleting viral virulence factors and/or arming various therapeutic genes have displayed better therapeutic effects in multiple tumor models.
Moreover, the combination of OVs with other cancer immunotherapeutic approaches, such as immune checkpoint inhibitors and CAR-T cells, has the potential to improve the outcome in cancer patients. This will open up new possibilities for the application of OVs in cancer treatment, especially for personalized cancer therapies.
论文信息
- 作者
- Liu X、Zhao J、Li X、Lao F、Fang M
- 单位
- CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.China
- 文献类型
- 综述
- 期刊
- Vaccines2022 Sep 17
- 原文标识
- PubMed 36146629 · DOI 10.3390/vaccines10091552
在 PubMed 查看 → 出版商原文（DOI） 全文 PDF（PMC）· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →