CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
CAR-T 细胞治疗中的免疫效应细胞相关神经毒性综合征
英文原题：Immune effector cell associated neurotoxicity syndrome in chimeric antigen receptor-T cell therapy.
查看英文原题
Immune effector cell associated neurotoxicity syndrome in chimeric antigen receptor-T cell therapy.
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中文摘要
嵌合抗原受体（CAR）-T细胞疗法正在成为某些血液系统恶性肿瘤治疗的重要手段。虽然CAR-T 细胞在某些血液系统恶性肿瘤中产生了强有力的应答，但与治疗相关的毒性限制了其应用。免疫效应细胞相关神经毒性综合征（ICANS）是一种可能危及生命的神经毒性，常发生于CAR-T 细胞治疗中。在此，我们将讨论ICANS、其治疗、可能的机制以及针对CAR-T 细胞疗法这一关键局限性的潜在解决方案。随着CAR-T 细胞疗法领域的发展，需要改进治疗方法和策略以规避或克服ICANS，从而改善发病率、死亡率并降低CAR-T 细胞疗法的成本。这种严重的、危及生命的副作用需要被研究，以更好地理解其机制并开发治疗方法和替代策略。
展开英文摘要原文
Chimeric antigen receptor (CAR)-T cell therapy is an emerging staple in the treatment of certain hematological malignancies. While CAR-T cells have produced robust responses in certain hematological malignancies, toxicities associated with the therapy have limited their use. Immune Effector Cell Associated Neurotoxicity Syndrome (ICANS) is a potentially life-threatening neurotoxicity that commonly occurs with CAR-T cell therapy.
Here we will discuss ICANS, its treatment, possible mechanisms, and potential solutions to this critical limitation of CAR-T cell therapy. As the field of CAR-T cell therapy evolves, improved treatments and methods to circumvent or overcome ICANS are necessary to improve morbidity, mortality, and decrease the cost of CAR-T cell therapy. This serious, life-threatening side effect needs to be studied to better understand its mechanisms and develop treatments and alternative strategies.
论文信息
- 作者
- Sterner RC、Sterner RM
- 第一作者单位
- School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, United States.United States
- 通讯作者单位
- Department of Surgery, Mayo Clinic, Rochester, MN, United States.United States
- 文献类型
- 综述
- 期刊
- Frontiers in immunology2022
- 原文标识
- PubMed 36081506 · DOI 10.3389/fimmu.2022.879608
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