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肿瘤免疫治疗中 CAR-T 细胞生产的潜在解决方案

英文原题:Potential solutions for manufacture of CAR T cells in cancer immunotherapy.

查看英文原题

Potential solutions for manufacture of CAR T cells in cancer immunotherapy.

PubMed 2022/09/05(内容时间) Nat Commun Q1 · IF 18.1(JCR 2025)

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中文摘要

CAR-T 细胞疗法是一种有效的癌症治疗方法,但生物学和制造方面的障碍阻碍了其广泛突破。尽管已经迈出了CAR细胞自动化生产的第一步,但仍需要新技术来实现对大量患者群体的治疗。

展开英文摘要原文

CAR T cell therapy is an effective cancer treatment, but biological and manufacturing hurdles hamper its broad breakthrough. Although the first step towards automated manufacture of CAR cells has been taken, new technologies are needed to enable the treatment of large patient groups.

论文信息

作者
Blache U、Popp G、Dünkel A、Koehl U、Fricke S
单位
Fraunhofer Institute for Cell Therapy and Immunology (IZI), Leipzig, Germany. Ulrich.Blache@izi.fraunhofer.de.Germany
文献类型
非美国政府资助研究
期刊
Nature communications2022 Sep 5
原文标识
PubMed 36064867 · DOI 10.1038/s41467-022-32866-0