RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
利用 IL-15 信号增强 NK 细胞介导的肿瘤免疫治疗
英文原题：Harnessing IL-15 signaling to potentiate NK cell-mediated cancer immunotherapy.
查看英文原题
Harnessing IL-15 signaling to potentiate NK cell-mediated cancer immunotherapy.
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中文摘要
自然杀伤（NK）细胞是固有免疫系统的重要组成部分，因其抗肿瘤特性而长期受到临床关注。NK细胞免疫的几乎各个方面都受到白细胞介素-15（IL-15）的调控，IL-15是共同γ链家族的一种细胞因子。目前多项临床试验正在使用IL-15或其类似物治疗各种癌症。此外，NK细胞正在被基因修饰以产生膜结合型或分泌型IL-15。在此，我们讨论IL-15信号在NK细胞免疫中的关键作用，并提供IL-15在NK细胞治疗中的最新概述。
展开英文摘要原文
Natural killer (NK) cells, a crucial component of the innate immune system, have long been of clinical interest for their antitumor properties. Almost every aspect of NK cell immunity is regulated by interleukin-15 (IL-15), a cytokine in the common -chain family. Several current clinical trials are using IL-15 or its analogs to treat various cancers.
Moreover, NK cells are being genetically modified to produce membrane-bound or secretory IL-15.
Here, we discuss the key role of IL-15 signaling in NK cell immunity and provide an up-to-date overview of IL-15 in NK cell therapy.
论文信息
- 作者
- Ma S、Caligiuri MA、Yu J
- 第一作者单位
- Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Los Angeles, CA 91010, USA; Hematologic Malignancies and Stem Cell Transplantation Institute, City of Hope National Medical Center, Los Angeles, CA 91010, USA.United States
- 通讯作者单位
- Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Los Angeles, CA 91010, USA; Hematologic Malignancies and Stem Cell Transplantation Institute, City of Hope National Medical Center, Los Angeles, CA 91010, USA; Comprehensive Cancer Center, City of Hope, Los Angeles, CA 91010, USA; Department of Immuno-Oncology, Beckman Research Institute, City of Hope, Los Angeles, CA 91010, USA. Electronic address: jiayu@coh.org.United States
- 文献类型
- 综述 · 非美国政府资助研究 · 美国 NIH 资助研究
- 期刊
- Trends in immunology2022 Oct
- 原文标识
- PubMed 36058806 · DOI 10.1016/j.it.2022.08.004
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