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前列腺癌的细胞与分子免疫治疗

英文原题:The Cellular and Molecular Immunotherapy in Prostate Cancer.

查看英文原题

The Cellular and Molecular Immunotherapy in Prostate Cancer.

PubMed 2022/08/22(内容时间) Vaccines (Basel) Q2 · IF 3.5(JCR 2025)

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中文摘要

近年来,免疫治疗已成为一种可行的癌症治疗选择。然而,多年来其原则已发生变化,目前涵盖了一系列针对癌症的免疫疗法。临床试验目前正在研究包括免疫检查点抑制剂(ICI)、CAR-T 细胞、靶向病毒的DNA疫苗以及过继性细胞疗法在内的单一疗法或药物联合治疗。根据正在进行的研究,该学科应通过整合患者定制免疫治疗、免疫检查点阻断剂、其他免疫治疗药物、激素治疗、放疗和化疗来取得进展。尽管发病率显著增加,免疫治疗仍可增强治疗效果并提高免疫应答。本研究汇总了晚期前列腺癌(PCa)免疫治疗的研究结果,表明可以探讨免疫治疗的现状,涵盖新发现、PCa治疗技术以及该领域持续演变中的研究前景。

展开英文摘要原文

In recent history, immunotherapy has become a viable cancer therapeutic option.

However, over many years, its tenets have changed, and it now comprises a range of cancer-focused immunotherapies. Clinical trials are currently looking into monotherapies or combinations of medicines that include immune checkpoint inhibitors (ICI), CART cells, DNA vaccines targeting viruses, and adoptive cellular therapy. According to ongoing studies, the discipline should progress by incorporating patient-tailored immunotherapy, immune checkpoint blockers, other immunotherapeutic medications, hormone therapy, radiotherapy, and chemotherapy.

Despite significantly increasing morbidity, immunotherapy can intensify the therapeutic effect and enhance immune responses. The findings for the immunotherapy treatment of advanced prostate cancer (PCa) are compiled in this study, showing that is possible to investigate the current state of immunotherapy, covering new findings, PCa treatment techniques, and research perspectives in the field's unceasing evolution.

论文信息

作者
Mukherjee AG、Wanjari UR、Prabakaran DS、Ganesan R、Renu K、Dey A、Vellingiri B、Kandasamy S
单位
Department of Biomedical Sciences, School of Biosciences and Technology, Vellore Institute of Technology (VIT), Vellore 632014, Tamil Nadu, India.India
文献类型
综述
期刊
Vaccines2022 Aug 22
原文标识
PubMed 36016257 · DOI 10.3390/vaccines10081370