CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
癌症免疫治疗的最新进展与挑战
英文原题：Recent Advances and Challenges in Cancer Immunotherapy.
查看英文原题
Recent Advances and Challenges in Cancer Immunotherapy.
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中文摘要
近年来，癌症免疫治疗彻底改变了肿瘤学领域。通过调动免疫系统治疗癌症，免疫检查点抑制、CAR-T 细胞治疗和癌症疫苗等新型免疫治疗策略大量涌现。本文综述当前免疫肿瘤学研究概况，重点讨论影响免疫治疗结局的因素，并介绍肿瘤免疫学基础研究的近期进展，尤其关注肿瘤微环境中的免疫抑制细胞如何调节抗肿瘤免疫。最后，我们探讨如何将对肿瘤免疫学基础机制的认识转化为新的免疫治疗策略。
展开英文摘要原文
Cancer immunotherapy has revolutionized the field of oncology in recent years. Harnessing the immune system to treat cancer has led to a large growth in the number of novel immunotherapeutic strategies, including immune checkpoint inhibition, chimeric antigen receptor T-cell therapy and cancer vaccination. In this review, we will discuss the current landscape of immuno-oncology research, with a focus on elements that influence immunotherapeutic outcomes.
We will also highlight recent advances in basic aspects of tumor immunology, in particular, the role of the immunosuppressive cells within the tumor microenvironment in regulating antitumor immunity. Lastly, we will discuss how the understanding of basic tumor immunology can lead to the development of new immunotherapeutic strategies.
论文信息
- 作者
- Peterson C、Denlinger N、Yang Y
- 单位
- Division of Hematology, The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA.United States
- 文献类型
- 综述
- 期刊
- Cancers2022 Aug 17
- 原文标识
- PubMed 36010965 · DOI 10.3390/cancers14163972
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