癌症免疫治疗的神经系统不良事件

Cancer immunotherapy encompasses a wide range of treatment modalities that harness the anti-tumor effects of the immune system and have revolutionized oncological treatment in recent years, with approval for its use in more and more cancers.

However, it is not without side effects. Several neurological adverse events have been recognized associated with immune checkpoint inhibitors (ICI) and chimeric antigen receptor (CAR) T-cell therapy, the two main classes of cancer immunotherapy. With the increase in the prevalence of oncological diseases and this type of therapy, it is improbable that neurologists, oncologists, hematologists, and other healthcare professionals who deal with cancer patients will not encounter this type of neurologic complication in their practice in the following years. This article aims to review the epidemiology, clinical manifestations, diagnosis, and management of neurological complications associated with ICI and CAR T-cell therapy. A imunoterapia contra o c ncer engloba uma gama de modalidades de tratamento que aumentam os efeitos antitumorais do pr prio sistema imunol gico do paciente e revolucionaram o tratamento oncol gico nos ltimos anos, com aprova o para seu uso em cada vez mais neoplasias.

No entanto, n o sem efeitos colaterais. V rios eventos adversos neurol gicos foram reconhecidos associados aos inibidores de checkpoint imunol gico (ICI) e terapia de c lulas T com receptor de ant geno quim rico (CAR-T), as duas principais classes de imunoterapia contra o c ncer.

Com o aumento da preval ncia de doen as oncol gicas e desse tipo de terapia, improv vel que neurologistas, oncologistas, hematologistas e demais profissionais de sa de que lidam com pacientes com c ncer n o encontrem esse tipo de complica o neurol gica em sua pr tica nos pr ximos anos. Este artigo tem como objetivo revisar a epidemiologia, as manifesta es cl nicas, o diagn stico e o manejo das complica es neurol gicas associadas terapia com ICI e c lulas CAR-T