CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
CAR-T 细胞：以癌细胞表面受体为癌症治疗靶点
英文原题：CAR T Cells: Cancer Cell Surface Receptors Are the Target for Cancer Therapy.
查看英文原题
CAR T Cells: Cancer Cell Surface Receptors Are the Target for Cancer Therapy.
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中文摘要
免疫疗法已成为治疗癌症的重要策略。一种增强免疫系统攻击肿瘤能力的方法（增强抗原结合）。通过过继转移嵌合抗原受体（CAR）T细胞靶向杀伤恶性细胞是一种有前景的癌症免疫治疗技术。为此，借助基因工程，患者的免疫细胞被装载具有特定抗原结合能力的嵌合受体，并激活细胞毒性T淋巴细胞。这提高了免疫细胞的效力并破坏癌细胞。本综述讨论了CAR-T 细胞的基本结构和功能，以及如何识别抗原靶点以治疗不同癌症，并探讨该癌症治疗方法的缺点。
展开英文摘要原文
Immunotherapy has become a prominent strategy for the treatment of cancer. A method that improves the immune system's ability to attack a tumor (Enhances antigen binding). Targeted killing of malignant cells by adoptive transfer of chimeric antigen receptor (CAR) T cells is a promising immunotherapy technique in the treatment of cancers.
For this purpose, the patient's immune cells, with genetic engineering aid, are loaded with chimeric receptors that have particular antigen binding and activate cytotoxic T lymphocytes. That increases the effectiveness of immune cells and destroying cancer cells. This review discusses the basic structure and function of CAR-T cells and how antigenic targets are identified to treat different cancers and address the disadvantages of this treatment for cancer.
论文信息
- 作者
- Shademan B、Karamad V、Nourazarian A、Avcı CB
- 单位
- Department of Medical Biology, Faculty of Medicine, EGE University, Izmir, Turkey.Turkey
- 文献类型
- 综述
- 期刊
- Advanced pharmaceutical bulletin2022 May
- 原文标识
- PubMed 35935042 · DOI 10.34172/apb.2022.051
在 PubMed 查看 → 出版商原文（DOI） 全文 PDF（PMC）· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →