CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
肿瘤免疫治疗中肿瘤相关巨噬细胞极化的调控
英文原题：Shaping Polarization Of Tumor-Associated Macrophages In Cancer Immunotherapy.
查看英文原题
Shaping Polarization Of Tumor-Associated Macrophages In Cancer Immunotherapy.
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中文摘要
不同刺激可使巨噬细胞极化为M1和M2两种基本类型。肿瘤微环境（TME）中的肿瘤相关巨噬细胞（TAM）由异质性亚群组成，包括抗肿瘤的M1表型和促肿瘤的M2表型。TAM在TME中主要发挥M2样促肿瘤作用，可调节血管生成、免疫抑制及肿瘤转移等多种恶性过程，因此成为癌症治疗研究热点。本综述聚焦TAM的三个方面。首先，总结巨噬细胞极化及其对TME的影响；其次，强调癌症治疗的近期进展和挑战，以及M2样TAM在免疫检查点阻断和CAR-T 细胞治疗中的作用；最后，讨论与TAM极化相关的信号通路等因素，以及靶向TAM、使其重新极化为促炎M1表型以治疗癌症的潜在策略。
展开英文摘要原文
Different stimuli can polarize macrophages into two basic types, M1 and M2. Tumor-associated macrophages (TAMs) in the tumor microenvironment (TME) are composed of heterogeneous subpopulations, which include the M1 anti-tumor and M2 pro-tumor phenotypes. TAMs predominantly play a M2-like tumor-promoting role in the TME and regulate various malignant effects, such as angiogenesis, immune suppression, and tumor metastasis; hence, TAMs have emerged as a hot topic of research in cancer therapy.
This review focuses on three main aspects of TAMs. First, we summarize macrophage polarization along with the effects on the TME. Second, recent advances and challenges in cancer treatment and the role of M2-like TAMs in immune checkpoint blockade and CAR-T cell therapy are emphasized.
Finally, factors, such as signaling pathways, associated with TAM polarization and potential strategies for targeting TAM repolarization to the M1 pro-inflammatory phenotype for cancer therapy are discussed.
论文信息
- 作者
- Gao J、Liang Y、Wang L
- 第一作者单位
- Beijing Tongren Hospital, Capital Medical University, Beijing, China.China
- 通讯作者单位
- Department of Hematology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.China
- 文献类型
- 综述 · 非美国政府资助研究
- 期刊
- Frontiers in immunology2022
- 原文标识
- PubMed 35844605 · DOI 10.3389/fimmu.2022.888713
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