CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
靶向聚糖的 CAR 治疗：糖基化 CAR 的问世
英文原题：Targeting glycans for CAR therapy: The advent of sweet CARs.
查看英文原题
Targeting glycans for CAR therapy: The advent of sweet CARs.
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中文摘要
嵌合抗原受体（CAR）T细胞疗法改变了血液系统恶性肿瘤的治疗模式，但对实体瘤的疗效不及血液肿瘤。实体瘤中CAR-T 细胞面临的主要障碍是肿瘤特异性抗原稀缺，以及敌对且复杂的肿瘤微环境。糖基化是糖类转录后添加到蛋白质或脂质上的过程，在癌症中常严重失调。癌细胞表达的异常糖基化糖蛋白具有肿瘤特异性，可作为CAR-T 治疗的独特靶点。肿瘤基质细胞也表达异常糖蛋白，因此同样可能成为糖链结合型CAR-T 的靶标。本综述讨论CAR-T 治疗实体瘤的现状、癌症糖蛋白组作为治疗靶点的潜力，以及糖链结合型CAR-T 疗法的发展格局与未来方向。
展开英文摘要原文
Chimeric antigen receptor (CAR) T cell therapy has created a paradigm shift in the treatment of hematologic malignancies but has not been as effective toward solid tumors. For such tumors, the primary obstacles facing CAR T cells are scarcity of tumor-specific antigens and the hostile and complex tumor microenvironment. Glycosylation, the process by which sugars are post-translationally added to proteins or lipids, is profoundly dysregulated in cancer.
Abnormally glycosylated glycoproteins expressed on cancer cells offer unique targets for CAR T therapy as they are specific to tumor cells. Tumor stromal cells also express abnormal glycoproteins and thus also have the potential to be targeted by glycan-binding CAR T cells. This review will discuss the state of CAR T cells in the therapy of solid tumors, the cancer glycoproteome and its potential for use as a therapeutic target, and the landscape and future of glycan-binding CAR T cell therapy.
论文信息
- 作者
- Raglow Z、McKenna MK、Bonifant CL、Wang W、Pasca di Magliano M、Stadlmann J、Penninger JM、Cummings RD
- 第一作者单位
- Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.United States
- 通讯作者单位
- Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA; Programs in Cancer Biology, Cellular and Molecular Biology, and Immunology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: dmarkov@med.umich.edu.United States
- 文献类型
- 综述 · 美国 NIH 资助研究 · 非美国政府资助研究
- 期刊
- Molecular therapy : the journal of the American Society of Gene Therapy2022 Sep 7
- 原文标识
- PubMed 35821636 · DOI 10.1016/j.ymthe.2022.07.006
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