RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
白细胞介素 15 在细胞免疫治疗癌症中的应用
英文原题：Interleukin 15 in Cell-Based Cancer Immunotherapy.
查看英文原题
Interleukin 15 in Cell-Based Cancer Immunotherapy.
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中文摘要
基于细胞的癌症免疫疗法，如嵌合抗原受体（CAR）工程化T细胞和自然杀伤（NK）细胞疗法，已成为癌症治疗的一项革命性新支柱。白细胞介素15（IL-15）是一种强效免疫刺激性细胞因子，可增强T和NK细胞免疫应答；其可靠性和效力显示有望提高现有细胞疗法的治疗效果。IL-15在结构上与白细胞介素2（IL-2）相似，可支持CD8+记忆T细胞持续存在，同时抑制IL-2诱导的T细胞死亡，从而更好地维持长期抗肿瘤免疫。本文综述IL-15生物学、IL-15和/或其衍生物作为免疫治疗药物给药的研究，以及过继细胞治疗中经IL-15强化的免疫细胞。还讨论将IL-15纳入细胞免疫治疗的优势和挑战，并提出未来研究方向。
展开英文摘要原文
Cell-based cancer immunotherapy, such as chimeric antigen receptor (CAR) engineered T and natural killer (NK) cell therapies, has become a revolutionary new pillar in cancer treatment. Interleukin 15 (IL-15), a potent immunostimulatory cytokine that potentiates T and NK cell immune responses, has demonstrated the reliability and potency to potentially improve the therapeutic efficacy of current cell therapy.
Structurally similar to interleukin 2 (IL-2), IL-15 supports the persistence of CD8 + memory T cells while inhibiting IL-2-induced T cell death that better maintains long-term anti-tumor immunity. In this review, we describe the biology of IL-15, studies on administrating IL-15 and/or its derivatives as immunotherapeutic agents, and IL-15-armored immune cells in adoptive cell therapy.
We also discuss the advantages and challenges of incorporating IL-15 in cell-based immunotherapy and provide directions for future investigation.
论文信息
- 作者
- Zhou Y、Husman T、Cen X、Tsao T、Brown J、Bajpai A、Li M、Zhou K
- 单位
- Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, CA 90095, USA.United States
- 文献类型
- 综述
- 期刊
- International journal of molecular sciences2022 Jun 30
- 原文标识
- PubMed 35806311 · DOI 10.3390/ijms23137311
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