CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
HER-2 阳性乳腺癌的免疫学景观
英文原题：Immunological Landscape of HER-2 Positive Breast Cancer.
查看英文原题
Immunological Landscape of HER-2 Positive Breast Cancer.
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中文摘要
了解HER2+乳腺癌中免疫应答的生物学方面对于在这些患者中实施新的治疗策略至关重要。众所周知，抗HER2治疗改善了该人群的生存率，但仍有相当比例的患者可能复发，这使得科学界需要揭示耐药机制并确定如何克服它们。本系统综述指出了曲妥珠单抗和其他药物靶向癌细胞的免疫机制，同时概述了研究免疫检查点阻断的主要试验。最后，我们报告了抗HER2疫苗，并附有一张示例其作用机制的图。
展开英文摘要原文
Understanding the biological aspects of immune response in HER2+ breast cancer is crucial to implementing new treatment strategies in these patients. It is well known that anti-HER2 therapy has improved survival in this population, yet a substantial percentage may relapse, creating a need within the scientific community to uncover resistance mechanisms and determine how to overcome them.
This systematic review indicates the immunological mechanisms through which trastuzumab and other agents target cancer cells, also outlining the main trials studying immune checkpoint blockade.
Finally, we report on anti-HER2 vaccines and include a figure exemplifying their mechanisms of action.
论文信息
- 作者
- Moragon S、Hernando C、Martinez-Martinez MT、Tapia M、Ortega-Morillo B、Lluch A、Bermejo B、Cejalvo JM
- 单位
- Department of Medical Oncology, INCLIVA Biomedical Research Institute, University of Valencia, 46010 Valencia, Spain.Spain
- 文献类型
- 综述
- 期刊
- Cancers2022 Jun 28
- 原文标识
- PubMed 35804943 · DOI 10.3390/cancers14133167
在 PubMed 查看 → 出版商原文（DOI） 全文 PDF（PMC）· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →