RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
外周 NK 细胞动态变化预测接受免疫检查点抑制剂二线治疗的 PD-L1 阳性非小细胞肺癌患者结局
英文原题：Dynamic Changes of Peripheral NK Cells Predict Outcome in Patients with PD-L1 Positive Non-small-cell Lung Cancer Undergoing Immune Checkpoint Inhibitors as Second-line Therapy.
查看英文原题
Dynamic Changes of Peripheral NK Cells Predict Outcome in Patients with PD-L1 Positive Non-small-cell Lung Cancer Undergoing Immune Checkpoint Inhibitors as Second-line Therapy.
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中文摘要
本研究评估41名非小细胞肺癌（NSCLC）患者在接受二线抗PD-1/PD-L1治疗前后外周血免疫细胞比例的变化，并分析淋巴细胞亚群变化与临床应答、无进展生存期（PFS）及总生存期（OS）的关系。治疗后所有淋巴细胞亚群的中位水平均有上升，但只有NK细胞升高达到统计学显著。治疗后NK细胞水平较高与临床获益相关。多变量分析显示，肿瘤PD-L1比例评分≥1%及治疗后NK细胞计数较高，均可预测更长的PFS和OS。两项因素同时存在者生存期更长。
展开英文摘要原文
We evaluated immune cell frequencies in peripheral blood samples of 41 NSCLC patients before and after second-line therapy with anti-PD-1/PD-L1 agents. Changes in lymphocyte subsets and their correlation with clinical response, progression-free survival (PFS), and overall survival (OS) were analyzed.
We observed an increase in median values of all lymphocyte subsets, being significant only for NK cells. A correlation was retrieved between higher post-treatment NK cell level and clinical benefit . On multivariate analysis, PD-L1 tumor proportion score 1% and higher post-treatment NK cell counts were predictive of longer PFS and OS. Co-presence of these factors was characterized by longer survival.
论文信息
- 作者
- Nelli F、Panichi V、Fabbri A、Natoni F、Giannarelli D、Topini G、Virtuoso A、Giron Berrios JR
- 单位
- Department of Oncology and Hematology, Medical Oncology, Central Hospital of Belcolle, Viterbo, Italy.Italy
- 期刊
- Cancer investigation2022 Sep
- 原文标识
- PubMed 35736808 · DOI 10.1080/07357907.2022.2092635