CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题：Can mesenchymal stem cells derived from adipose tissue and their conditioned medium improve ovarian functions? A mini-review.
Can mesenchymal stem cells derived from adipose tissue and their conditioned medium improve ovarian functions? A mini-review.
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稳定的卵巢功能是生殖系统正常运作的重要因素。多囊卵巢综合征、卵巢早衰（POF）和卵巢癌等卵巢功能相关疾病，是全球女性不孕和死亡的重要原因。尽管人们尝试了多种方法，目前仍缺乏有效治疗；但间充质干细胞（MSC）疗法，尤其是脂肪组织来源的MSC，因易于分离且来源易得而受到关注。此外，有研究认为MSC条件培养液（CM）可修复受损组织，并具有较高免疫相容性。本文小综述将总结脂肪组织来源MSC及其条件培养液对卵巢功能和相关疾病的影响。
Stable ovarian function is a key factor in the performance of the reproductive system. In contrast, some ovarian function-related diseases, such as polycystic ovarian syndrome, premature ovarian failure (POF), and ovarian cancer, are the main cause of infertility and death of women around the world.
Despite multiple attempts, there are no effective tools against these conditions; however, mesenchymal stem cell-based therapy, especially using adipose tissue, has attracted much attention in medicine in light of its advantages such as easy isolation and accessibility. Conversely, it has been suggested that MSC-conditioned medium (CM) can restore injured tissues and has high immunocompatibility. So, here, we will summarize the effects of administration of MSCs and CM derived from adipose tissue on ovarian functions and related diseases.
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