RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
淋巴结转移推动全身性疾病
英文原题：Lymph node metastasis fuels systemic disease.
查看英文原题
Lymph node metastasis fuels systemic disease.
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中文摘要
淋巴结（LN）转移对全身肿瘤进展的功能影响数十年来一直是一个有争议的问题。在他们最近发表于 Cell 的论文中，Reticker-Flynn 等人证明，对自然杀伤（NK）细胞控制的序贯逃逸和干扰素（IFN）依赖性表观遗传适应增强了 LN 转移的概率。此外，他们表明，一旦形成，LN 转移会扩大全身外周耐受并促进远处器官转移。
展开英文摘要原文
The functional impact of lymph node (LN) metastasis on systemic tumor progression has been a controversial question for decades. In their recent paper published in Cell, Reticker-Flynn et al. demonstrate that sequential evasion of natural killer (NK) cell control and interferon (IFN)-dependent epigenetic adaptation enhances the probability of LN metastasis.
Further, they show that, once formed, LN metastases expand systemic peripheral tolerance and promote distant organ metastasis.
论文信息
- 作者
- Ventre KS、Karakousi T、Lund AW
- 第一作者单位
- Ronald O. Perelman Department of Dermatology, New York University (NYU) Grossman School of Medicine, New York, NY, USA.United States
- 通讯作者单位
- Ronald O. Perelman Department of Dermatology, New York University (NYU) Grossman School of Medicine, New York, NY, USA; Department of Pathology, NYU Grossman School of Medicine, New York, NY, USA; Laura and Isaac Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY, USA. Electronic address: amanda.lund@nyulangone.org.United States
- 文献类型
- 美国 NIH 资助研究 · 非美国政府资助研究 · 评论
- 期刊
- Trends in cancer2022 Aug
- 原文标识
- PubMed 35717536 · DOI 10.1016/j.trecan.2022.06.003