RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
外泌体 circRNA 在肿瘤免疫和癌症进展中的作用
英文原题：Roles of exosomal circRNAs in tumour immunity and cancer progression.
查看英文原题
Roles of exosomal circRNAs in tumour immunity and cancer progression.
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中文摘要
肿瘤免疫在癌症发生发展中发挥重要作用。肿瘤免疫治疗是抗肿瘤治疗的重要组成部分。外泌体是一种细胞外囊泡，作为细胞间通讯和分子转移的介质，在肿瘤免疫中发挥重要作用。环状RNA（circRNA）是一种新型非编码RNA，在外泌体中富集。在本综述中，我们描述了外泌体circRNA对多种免疫细胞的影响及其机制，包括巨噬细胞、中性粒细胞、T细胞和自然杀伤（NK）细胞。接下来，我们阐述了外泌体提取的最新进展。此外，还描述了外泌体circRNA作为潜在预后和药物敏感性标志物的功能。我们展示了外泌体circRNA在调节肿瘤免疫、预测患者结局和评估药物疗效方面的巨大前景。
展开英文摘要原文
Tumour immunity plays an important role in the development of cancer. Tumour immunotherapy is an important component of antitumour therapy. Exosomes, a type of extracellular vesicle, act as mediators of intercellular communication and molecular transfer and play an essential role in tumour immunity.
Circular RNAs (circRNAs) are a new type of noncoding RNA that are enriched within exosomes. In this review, we describe the effects of exosomal circRNAs on various immune cells and the mechanisms of these effects, including macrophages, neutrophils, T cells, and Natural killer (NK) cells. Next, we elaborate on the latest progress of exosome extraction.
In addition, the function of exosomal circRNAs as a potential prognostic and drug sensitivity marker is described.
We present the great promise of exosomal circRNAs in regulating tumour immunity, predicting patient outcomes, and evaluating drug efficacy.
论文信息
- 作者
- Tuo B、Chen Z、Dang Q、Chen C、Zhang H、Hu S、Sun Z
- 第一作者单位
- Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.China
- 通讯作者单位
- Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China. fccsunzq@zzu.edu.cn.China
- 文献类型
- 综述 · 非美国政府资助研究
- 期刊
- Cell death & disease2022 Jun 9
- 原文标识
- PubMed 35676257 · DOI 10.1038/s41419-022-04949-9
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