CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
儿童急性淋巴细胞白血病患者接受 CAR-T 细胞治疗后 HIV 检测假阳性结果的病例系列：关于如何避免和解决诊断困境的指导
英文原题：Case Series of False-Positive HIV Test Results in Pediatric Acute Lymphoblastic Leukemia Patients Following Chimeric Antigen Receptor T-Cell Therapy: Guidance on How to Avoid and Resolve Diagnostic Dilemmas.
查看英文原题
Case Series of False-Positive HIV Test Results in Pediatric Acute Lymphoblastic Leukemia Patients Following Chimeric Antigen Receptor T-Cell Therapy: Guidance on How to Avoid and Resolve Diagnostic Dilemmas.
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中文摘要
CAR-T 细胞细胞疗法已获批用于治疗复发/难治性急性淋巴细胞白血病B-ALL的儿科患者。慢病毒载体技术经过对HIV-1的高度改造，通过整合到宿主基因组中来诱导稳定、长期的转基因表达。这种整合可能会干扰HIV-1 NAAT，产生假阳性结果。对于接受此类治疗的儿科B-ALL患者，HIV诊断检测的指南尚缺乏。在此，我们报告了一系列病例，展示了CAR-T 细胞患者中HIV-1 NAAT检测产生假阳性结果的情形，强调了在该患者群体中仔细选择检测方法及实施检测的重要性。
展开英文摘要原文
Chimeric antigen receptor T-cell (CAR-T) Cell Therapy is approved for the treatment of pediatric patients with relapsed/refractory acute lymphoblastic leukemia B-ALL. Lentiviral vector technology, highly modified from HIV-1, is used to induce stable, long-term transgene expression by integration into the host genome. This integration may interfere with HIV-1 NAAT producing false-positive results. Guidance for HIV diagnostic testing in pediatric B-ALL undergoing this type of therapy is lacking.
Herein, we report case series with presented scenarios in which HIV-1 NAAT testing among CAR-T cell patients produced false-positive results, highlighting the importance careful assay selection and performance among this patient population.
论文信息
- 作者
- Alali M、Carlucci JG、Christenson J、Prather C、Skiles J
- 第一作者单位
- Department of Pediatrics, Ryan White Center for Pediatric Infectious Diseases and Global Health, Indiana University School of Medicine, Indianapolis, Indiana, USA.Italy
- 通讯作者单位
- Department of Pediatrics, Section of Hematology/Oncology, Indiana University School of Medicine, Indianapolis, Indiana, USA.Italy
- 期刊
- Journal of the Pediatric Infectious Diseases Society2022 Aug 30
- 原文标识
- PubMed 35512447 · DOI 10.1093/jpids/piac028