RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
推进针对癌症的 NK 细胞疗法
英文原题：Advancing natural killer therapies against cancer.
查看英文原题
Advancing natural killer therapies against cancer.
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中文摘要
基于NK细胞的抗癌疗法正在兴起，但要优化这些治疗，仍需完善对NK细胞功能的理解。在本期，Pan等人（2022）表明，促凋亡分子（如BH3模拟物）与NK细胞协同作用，诱导肿瘤细胞中线粒体驱动的凋亡，从而增强NK细胞疗法的疗效。
展开英文摘要原文
Natural killer (NK)-based therapies against cancer are emerging, but the understanding of NK cell functions needs to be completed to optimize these treatments. In this issue, Pan et al. (2022) show that pro-apoptotic molecules, such as BH3-mimetics, synergize with NK cells to induce mitochondria-driven apoptosis in tumor cells, thereby enhancing the efficacy of NK cell therapies.
论文信息
- 作者
- Narni-Mancinelli E、Vivier E
- 单位
- Aix Marseille Univ, CNRS, INSERM, CIML, Marseille, France. Electronic address: narni@ciml.univ-mrs.fr.France
- 文献类型
- 非美国政府资助研究 · 评论
- 期刊
- Cell2022 Apr 28
- 原文标识
- PubMed 35487189 · DOI 10.1016/j.cell.2022.04.006