RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
用于肿瘤免疫治疗的人原代 NK 和 T 细胞 CRISPR 基因编辑
英文原题：CRISPR Gene Editing of Human Primary NK and T Cells for Cancer Immunotherapy.
查看英文原题
CRISPR Gene Editing of Human Primary NK and T Cells for Cancer Immunotherapy.
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中文摘要
T细胞和NK细胞等免疫细胞的抗肿瘤活性使其成为适应性癌症免疫治疗的有前景的治疗方案。增强它们对恶性肿瘤的细胞毒性作用并克服它们在肿瘤微环境（TME）中的抑制，可能会提高它们治疗癌症的疗效。成簇规律间隔短回文重复序列（CRISPR）基因组编辑已成为增强免疫细胞抗肿瘤活性的最常用工具之一。在这篇综述中，我们重点介绍了CRISPR/Cas9基因编辑和工程化策略在癌症免疫治疗中的应用和实用性。此外，我们综述了几种研究CRISPR脱靶效应的方法。
展开英文摘要原文
Antitumor activity of immune cells such as T cells and NK cells has made them auspicious therapeutic regimens for adaptive cancer immunotherapy. Enhancing their cytotoxic effects against malignancies and overcoming their suppression in tumor microenvironment (TME) may improve their efficacy to treat cancers.
Clustered, regularly interspaced short palindromic repeats (CRISPR) genome editing has become one of the most popular tools to enhance immune cell antitumor activity. In this review we highlight applications and practicability of CRISPR/Cas9 gene editing and engineering strategies for cancer immunotherapy.
In addition, we have reviewed several approaches to study CRISPR off-target effects.
论文信息
- 作者
- Elmas E、Saljoughian N、de Souza Fernandes Pereira M、Tullius BP、Sorathia K、Nakkula RJ、Lee DA、Naeimi Kararoudi M
- 第一作者单位
- Molecular, Cellular and Developmental Biology Graduate Program, The Ohio State University, Columbus, OH, United States.United States
- 通讯作者单位
- Center for Childhood Cancer and Blood Diseases, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, United States.United States
- 文献类型
- 综述
- 期刊
- Frontiers in oncology2022
- 原文标识
- PubMed 35449580 · DOI 10.3389/fonc.2022.834002
在 PubMed 查看 → 出版商原文（DOI） 全文 PDF（PMC）· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →