CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
用于肿瘤免疫治疗的合成 HLA 非依赖性 T 细胞受体
英文原题：Synthetic HLA-independent T cell receptors for cancer immunotherapy.
查看英文原题
Synthetic HLA-independent T cell receptors for cancer immunotherapy.
分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。
中文摘要
CAR-T 细胞在血液系统恶性肿瘤中效果显著，但表达低水平抗原的肿瘤细胞可逃逸清除。在Nature Medicine中，Mansilla-Soto等人设计了新的嵌合受体，将抗体的可变区直接与T细胞受体链连接，并以改善的抗原敏感性识别肿瘤细胞。
展开英文摘要原文
CAR T cells are remarkably effective in hematologic malignancies, but tumor cells expressing low antigen levels can escape elimination. In Nature Medicine, Mansilla-Soto et al. design new chimeric receptors that link the variable regions of antibodies directly to T cell receptor chains and recognize tumor cells with improved antigen sensitivity.
论文信息
- 作者
- Simon S、Bugos G、Riddell SR
- 第一作者单位
- Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA.United States
- 通讯作者单位
- Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA; Department of Immunology, University of Washington, Seattle, WA 98109, USA; Department of Medicine, University of Washington, Seattle, WA 98109, USA. Electronic address: sriddell@fredhutch.org.United States
- 期刊
- Cancer cell2022 Apr 11
- 原文标识
- PubMed 35413270 · DOI 10.1016/j.ccell.2022.03.009