不适合移植的大 B 细胞淋巴瘤二线使用 axicabtagene ciloleucel：ALYCANTE 最终分析
Second-line axicabtagene ciloleucel in large B-cell lymphoma ineligible for transplantation: ALYCANTE final analysis.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
扩增自然杀伤（ANK）细胞疗法治疗成人 T 细胞白血病/淋巴瘤（ATL）的疗效及 ANK 疗法的未来展望
英文原题：Effectiveness of Amplified Natural Killer (ANK) Therapy for Adult T-cell Leukemia/Lymphoma (ATL) and Future Prospects of ANK Therapy.
查看英文原题
Effectiveness of Amplified Natural Killer (ANK) Therapy for Adult T-cell Leukemia/Lymphoma (ATL) and Future Prospects of ANK Therapy.
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中文摘要
扩增自然杀伤（ANK）疗法经过改良，以提高原始（LAK）免疫疗法的安全性和疗效。该方法是从患者自身血液中分离自然杀伤（NK）细胞，对NK细胞进行培养和扩增，特别是增强其攻击癌症的能力，然后回输用于治疗。它通常对所有癌症有效。本文介绍的两例病例以及其他接受治疗的病例表明，ANK疗法对ATL非常安全且有效。进一步研究表明，ANK疗法而非化疗，很可能成为ATL的一线疗法。此外，NK细胞活性低意味着细菌负荷积累。因此，使用高剂量活化NK细胞的ANK疗法可能不仅对ATL和癌症有效，而且对慢性细菌和病毒感染患者也有效。
展开英文摘要原文
Amplified Natural Killer (ANK) therapy is modified to increase the safety and efficacy of the original (LAK) immunotherapy. It is a method of removing natural killer (NK) cells from the patient's own blood, culturing and amplifying the NK cells, specifically increasing their ability to attack cancer and returning them for treatment. It is generally effective against all cancers. The two cases presented here and the other treated cases show that ANK therapy is very safe and effective against ATL.
Further research suggests that ANK therapy, rather than chemotherapy, is likely to be the first-line therapy for ATL.
In addition, low activity of NK cells means accumulation of bacterial load.
Therefore, ANK therapy with high doses of activated NK cells may be effective not only for ATL and cancer, but also for patients with chronic bacterial and viral infections.
论文信息
- 作者
- Nagai K、Nagai S
- 单位
- Ebino Centro Clinic, Ebino City, Miyazaki, Japan.Japan
- 期刊
- Cancer medicine journal2022 Jun
- 原文标识
- PubMed 35403177
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