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异基因干细胞移植在多发性骨髓瘤中的当前作用

英文原题:Current Role of Allogeneic Stem Cell Transplantation in Multiple Myeloma.

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Current Role of Allogeneic Stem Cell Transplantation in Multiple Myeloma.

PubMed 2022/04/04(内容时间) Oncol Ther Q2 · IF 3.4(JCR 2025)

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中文摘要

过去数年,多发性骨髓瘤的治疗取得重大进展。然而,骨髓瘤仍无法治愈;具有高危细胞遗传学特征或疾病晚期患者的生存情况更差。对部分患者而言,只有异体移植可能具有治愈潜力。然而,较高的非复发死亡率和慢性移植物抗宿主病发生率,使这一治疗方式备受争议。本综述将讨论一线及延迟实施异体移植的作用。

展开英文摘要原文

Major progress in the treatment of multiple myeloma has been made in the last several years.

However, myeloma remains incurable and patients with high-risk cytogenetics or advanced stage disease have an even worsen survival. Only allogeneic transplantation may have curative potential in some patients.

However, the high non-relapse mortality and incidence of chronic graft-versus-host disease have raised controversy regarding this procedure. In this review, we will address the role of upfront and delayed allogeneic transplant.

论文信息

作者
Claveau JS、Buadi FK、Kumar S
第一作者单位
Division of Hematology, Mayo Clinic, 200 First St. SW, Rochester, MN, 55905, USA.United States
通讯作者单位
Division of Hematology, Mayo Clinic, 200 First St. SW, Rochester, MN, 55905, USA. Kumar.Shaji@mayo.edu.United States
文献类型
综述
期刊
Oncology and therapy2022 Jun
原文标识
PubMed 35377068 · DOI 10.1007/s40487-022-00195-3