中文摘要
过去数年,多发性骨髓瘤的治疗取得重大进展。然而,骨髓瘤仍无法治愈;具有高危细胞遗传学特征或疾病晚期患者的生存情况更差。对部分患者而言,只有异体移植可能具有治愈潜力。然而,较高的非复发死亡率和慢性移植物抗宿主病发生率,使这一治疗方式备受争议。本综述将讨论一线及延迟实施异体移植的作用。
展开英文摘要原文
Major progress in the treatment of multiple myeloma has been made in the last several years.
However, myeloma remains incurable and patients with high-risk cytogenetics or advanced stage disease have an even worsen survival. Only allogeneic transplantation may have curative potential in some patients.
However, the high non-relapse mortality and incidence of chronic graft-versus-host disease have raised controversy regarding this procedure. In this review, we will address the role of upfront and delayed allogeneic transplant.
论文信息
- 作者
- Claveau JS、Buadi FK、Kumar S
- 第一作者单位
- Division of Hematology, Mayo Clinic, 200 First St. SW, Rochester, MN, 55905, USA.United States
- 通讯作者单位
- Division of Hematology, Mayo Clinic, 200 First St. SW, Rochester, MN, 55905, USA. Kumar.Shaji@mayo.edu.United States
- 文献类型
- 综述
- 期刊
- Oncology and therapy2022 Jun