CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
重编程线粒体代谢以对抗 CAR-T 细胞耗竭
英文原题：Rewiring mitochondrial metabolism to counteract exhaustion of CAR-T cells.
查看英文原题
Rewiring mitochondrial metabolism to counteract exhaustion of CAR-T cells.
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中文摘要
T细胞持续存在能力短、早期耗竭，是限制免疫疗法疗效和广泛应用的主要因素。耗竭T细胞和嵌合抗原受体（CAR）T细胞会上调与T细胞分化终止、需氧糖酵解和细胞凋亡相关的基因表达。在线粒体功能障碍和动力学异常等细胞耗竭特征中，这些变化被认为是典型标志。本文综述耗竭T细胞的线粒体特征，尤其讨论线粒体代谢和可塑性的不同方面。此外，我们提出一种新策略：重塑线粒体代谢，使T细胞摆脱耗竭；并靶向线粒体可塑性，以增强CAR-T 细胞疗效。
展开英文摘要原文
Short persistence and early exhaustion of T cells are major limits to the efficacy and broad application of immunotherapy. Exhausted T and chimeric antigen receptor (CAR)-T cells upregulate expression of genes associated with terminated T cell differentiation, aerobic glycolysis and apoptosis. Among cell exhaustion characteristics, impaired mitochondrial function and dynamics are considered hallmarks.
Here, we review the mitochondrial characteristics of exhausted T cells and particularly discuss different aspects of mitochondrial metabolism and plasticity.
Furthermore, we propose a novel strategy of rewiring mitochondrial metabolism to emancipate T cells from exhaustion and of targeting mitochondrial plasticity to boost CAR-T cell therapy efficacy.
论文信息
- 作者
- Huang Y、Si X、Shao M、Teng X、Xiao G、Huang H
- 第一作者单位
- Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, No. 79 Qingchun Road, Hangzhou, China.China
- 通讯作者单位
- Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, No. 79 Qingchun Road, Hangzhou, China. huanghe@zju.edu.cn.China
- 文献类型
- 综述 · 非美国政府资助研究
- 期刊
- Journal of hematology & oncology2022 Mar 28
- 原文标识
- PubMed 35346311 · DOI 10.1186/s13045-022-01255-x
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