RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
NK 细胞在癌症转移中不断变化的角色
英文原题：The changing role of natural killer cells in cancer metastasis.
查看英文原题
The changing role of natural killer cells in cancer metastasis.
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中文摘要
自然杀伤（NK）细胞是先天免疫细胞，对机体的抗肿瘤和抗转移防御至关重要。因此，新型疗法正在被开发，以利用NK细胞作为下一代免疫疗法的一部分来治疗转移性疾病患者。因此，我们必须研究转移性癌细胞与NK细胞在整个转移级联过程中如何相互作用。在本综述中，我们重点介绍了近期已开始回答这些问题的研究工作。我们探讨了癌细胞在转移各阶段的独特生物学特性如何改变NK细胞的基本生物学，包括癌细胞如何逃避免疫监视以及如何将NK细胞拉拢为促进转移的细胞。我们还讨论了这些知识的转化潜力。
展开英文摘要原文
Natural killer (NK) cells are innate immune cells that are critical to the body's antitumor and antimetastatic defense. As such, novel therapies are being developed to utilize NK cells as part of a next generation of immunotherapies to treat patients with metastatic disease.
Therefore, it is essential for us to examine how metastatic cancer cells and NK cells interact with each other throughout the metastatic cascade. In this Review, we highlight the recent body of work that has begun to answer these questions.
We explore how the unique biology of cancer cells at each stage of metastasis alters fundamental NK cell biology, including how cancer cells can evade immunosurveillance and co-opt NK cells into cells that promote metastasis.
We also discuss the translational potential of this knowledge.
论文信息
- 作者
- Chan IS、Ewald AJ
- 第一作者单位
- Department of Internal Medicine, Division of Hematology and Oncology, and.
- 通讯作者单位
- Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, and.
- 文献类型
- 美国 NIH 资助研究 · 非美国政府资助研究 · 综述
- 期刊
- The Journal of clinical investigation2022 Mar 15
- 原文标识
- PubMed 35289318 · DOI 10.1172/JCI143762
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