借力推动前列腺癌 CAR-T 细胞治疗进展
Piggybacking toward Progress for CAR T-Cell Therapy in Prostate Cancer.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
非洲裔男性前列腺癌背后的免疫机制：综述
英文原题：Immune mechanisms behind prostate cancer in men of African ancestry: A review.
查看英文原题
Immune mechanisms behind prostate cancer in men of African ancestry: A review.
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研究概要
AA 前列腺癌患者可能富集免疫原性表型。
中文摘要
背景
非洲血统（AA）男性前列腺癌患者结局较差。但近期一项评估前列腺癌患者接受树突状细胞疫苗西普鲁塞-T治疗的分析提示，AA患者的结局可能优于白人患者。
方法
重点回顾Medline收录的文章和ClinicalTrials.gov登记的临床试验。
结果
多项研究提示，AA前列腺癌患者的炎症性细胞浸润及细胞因子信号通路富集。本文概述可能促成免疫原性的基因组和转录组变化，并探讨AA患者宿主免疫和疫苗应答可能增强的差异。
结论
AA前列腺癌患者可能更富集免疫原性表型。仍需开展专门研究，更好理解造成现有癌症差异的免疫机制，并在这一人群中检验免疫疗法。
展开英文摘要原文
BACKGROUND
Men of African ancestry (AA) with prostate cancer suffer from worse outcomes. However, a recent analysis of patients treated with the dendritic cell vaccine sipuleucel-T for prostate cancer suggested that AA patients could have improved outcomes relative to whites.
METHODS
We conducted a focused literature review of Medline-indexed articles and clinical trials listed on clinicaltrials.gov.
RESULTS
We identify several studies pointing to enrichment of inflammatory cellular infiltrates and cytokine signaling among AA patients with prostate cancer. We outline potential genomic and transcriptomic alterations that may contribute to immunogenicity. Last, we investigate differences in host immunity and vaccine responsiveness that may be enhanced in AA patients.
CONCLUSIONS
AA patients with prostate cancer may be enriched for an immunogenic phenotype. Dedicated studies are needed to better understand the immune mechanisms that contribute to existing cancer disparities and test immune-based therapies in this population.
论文信息
- 作者
- Sentana-Lledo D、Sartor O、Balk SP、Einstein DJ
- 单位
- Division of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.Israel
- 文献类型
- 综述 · 美国政府（非公共卫生署）资助研究 · 美国 NIH 资助研究 · 非美国政府资助研究
- 期刊
- The Prostate2022 Jun
- 原文标识
- PubMed 35254710 · DOI 10.1002/pros.24333
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