CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
CAR-T 细胞疗法治疗肿瘤干细胞的希望：简短综述
英文原题：The Promise of CAR T-Cell Therapy for the Treatment of Cancer Stem Cells: A Short Review.
查看英文原题
The Promise of CAR T-Cell Therapy for the Treatment of Cancer Stem Cells: A Short Review.
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中文摘要
嵌合抗原受体（CAR）T细胞疗法是一种用于治疗多种肿瘤的复杂定制免疫疗法。免疫疗法通过利用人体自身的免疫系统来发现并摧毁恶性细胞。在CAR-T 疗法中，患者自身的免疫细胞经过基因工程改造，以识别和攻击癌症。采用CAR-T 细胞的治疗目前已在血液系统恶性肿瘤患者中显示出有前景的治疗效果，其在实体瘤中的安全性和可行性也已得到验证。在这篇综述中，我们将详细讨论CAR-T 细胞通过选择性靶向癌症干细胞（CSC）的细胞表面标志物来抑制CSC，从而最终改善各种类型癌症患者治疗反应的可能性。本综述涵盖了针对恶性肿瘤的癌症干细胞（CSC）靶向CAR-T 细胞的主要组成部分，从基础研究到临床应用。
展开英文摘要原文
Chimeric antigen receptor (CAR) T-cell therapy is a type of sophisticated tailored immunotherapy used to treat a variety of tumors. Immunotherapy works by utilizing the body's own immune system to discover and destroy malignant cells. In CAR-T therapy, a patient's own immune cells are genetically engineered to recognize and attack cancer. Treatments employing CAR T-cells are currently showing promising therapeutic results in patients with hematologic malignancies, and their safety and feasibility in solid tumors have been verified.
In this review, we will discuss in detail the likelihood that CAR Tcells inhibit cancer stem cells (CSCs) by selectively targeting their cell surface markers will ultimately improve the therapeutic response for patients with various forms of cancer. This review addresses the major components of cancer stem cell (CSC)-targeted CAR T-cells against malignancies, from bench to bedside.
论文信息
- 作者
- Poondla N、Sheykhhasan M、Akbari M、Samadi P、Kalhor N、Manoochehri H
- 第一作者单位
- Richmond University Medical Center, 355, Bard Avenue, Staten Island, New York 10310, United States.United States
- 通讯作者单位
- Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.Iran
- 文献类型
- 综述
- 期刊
- Current stem cell research & therapy2022
- 原文标识
- PubMed 35176990 · DOI 10.2174/1574888X17666220217101817