CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
复发性 B 细胞急性淋巴细胞白血病中 CAR-T 细胞治疗后的渗出性视网膜脱离
英文原题：Exudative Retinal Detachment Following Chimeric Antigen Receptor T-Cell Therapy in Relapsed B-Cell Acute Lymphoblastic Leukemia.
查看英文原题
Exudative Retinal Detachment Following Chimeric Antigen Receptor T-Cell Therapy in Relapsed B-Cell Acute Lymphoblastic Leukemia.
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中文摘要
嵌合抗原受体（CAR）T 细胞疗法已成为治疗多种血液系统恶性肿瘤的一种新方法，但眼部不良反应尚未得到充分描述。本报告介绍一名复发性 B 细胞急性淋巴细胞白血病儿童患者，该患者存在眼部受累并接受 CAR-T 细胞治疗，随后发生渗出性视网膜脱离，可能继发于 CAR-T 细胞治疗引发的炎症反应。《Ophthalmic Surgery, Lasers and Imaging Retina》2022；53：113–115。
展开英文摘要原文
Chimeric antigen receptor (CAR) T-cell therapy has become a novel approach in the treatment of many hematologic malignancies.
However, ocular adverse effects have not been well described. This report presents a case of a pediatric patient with relapsed B-cell acute lymphoblastic leukemia with ocular involvement treated with CAR T-cell therapy who developed an exudative retinal detachment likely secondary to an inflammatory response to CAR T-cell therapy. [ Ophthalmic Surg Lasers Imaging Retina . 2022;53:113-115.] .
论文信息
- 作者
- Khanna S、Mackin AG、Dao DT、Komati R、Morocco PC、LaBelle JL、Shah HA、Blair MP
- 文献类型
- 病例报告
- 期刊
- Ophthalmic surgery, lasers & imaging retina2022 Feb
- 原文标识
- PubMed 35148216 · DOI 10.3928/23258160-20220124-01