CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
多发性骨髓瘤的细胞免疫治疗：现状、挑战与未来方向
英文原题：Cellular Immunotherapies for Multiple Myeloma: Current Status, Challenges, and Future Directions.
查看英文原题
Cellular Immunotherapies for Multiple Myeloma: Current Status, Challenges, and Future Directions.
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中文摘要
尽管蛋白酶体抑制剂、免疫调节药物、靶向CD38抗体及自体干细胞移植（auto-SCT）显著改善新诊断多发性骨髓瘤（MM）患者的临床结局，但由于复发，MM仍无法治愈。近年来，CAR-T 细胞疗法的引入为难治性和复发性MM患者带来了希望。异基因SCT的移植物抗骨髓瘤效应则使一部分MM患者有望获得治愈。本文综述MM细胞免疫疗法的最新进展和挑战，重点讨论auto-SCT、异基因SCT和CAR-T 细胞疗法，并探讨未来方向，提出MM细胞疗法的具体治疗算法，以及基于微小残留病指导治疗的可能性。
展开英文摘要原文
Multiple myeloma (MM) remains incurable due to relapse, although the use of proteasome inhibitors, immunomodulatory drugs, CD38-targeting antibodies, and autologous stem cell transplantation (auto-SCT) significantly improve the clinical outcomes of patients with newly diagnosed MM.
In recent years, the introduction of chimeric antigen receptor T-cell (CAR T-cell) therapy has brought hope to patients with refractory and relapsed MM. The graft-versus-myeloma effect of allogeneic SCT provides the possibility for curing a subset of MM patients. In this review, we summarize the recent advances and challenges of cellular immunotherapies for MM, focusing on auto-SCT, allogeneic SCT, and CAR T-cell approaches.
We also discuss future directions, and propose a specific algorithm for cellular therapies for MM and probability of minimal residual disease-directed therapy.
论文信息
- 作者
- Yan ZL、Wang YW、Chang YJ
- 第一作者单位
- Deparment of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.China
- 通讯作者单位
- Peking University People's Hospital & Peking University Institute of Hematology, No 11 Xizhimen South Street, Beijing, 100044, China. rmcyj@bjmu.edu.cn.China
- 文献类型
- 综述
- 期刊
- Oncology and therapy2022 Jun
- 原文标识
- PubMed 35103936 · DOI 10.1007/s40487-022-00186-4
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