RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
脑内 NK 细胞：对脑肿瘤发生与治疗的意义
英文原题：NK cells in the brain: implications for brain tumor development and therapy.
查看英文原题
NK cells in the brain: implications for brain tumor development and therapy.
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中文摘要
自然杀伤（NK）细胞是先天淋巴样细胞，具有强大的抗肿瘤功能，使其成为针对恶性肿瘤的有前景的治疗工具。尽管NK细胞仅占脑部肿瘤浸润免疫细胞的一小部分，但关于其在中枢神经系统（CNS）病理生理学中作用的认识正在不断涌现。深度免疫抑制微环境以及肿瘤耐药机制所带来的挑战，使得探索增强NK细胞在原发性与转移性脑恶性肿瘤中治疗潜力的途径成为必要。在本综述中，我们总结了NK细胞在脑部肿瘤发病机制中的作用，并讨论了为利用其抗癌效应对抗原发性和转移性CNS肿瘤所探索的途径，包括治疗性NK细胞的来源、与其他治疗的联合，以及增强其细胞毒性的新型工程化方法。我们还重点介绍了基于NK细胞疗法的相关临床前证据和临床试验。
展开英文摘要原文
Natural killer (NK) cells are innate lymphoid cells with robust antitumor functions rendering them promising therapeutic tools against malignancies. Despite constituting a minor fraction of the immune cells infiltrating tumors in the brain, insights into their role in central nervous system (CNS) pathophysiology are emerging. The challenges posed by a profoundly immunosuppressive microenvironment as well as by tumor resistance mechanisms necessitate exploring avenues to enhance the therapeutic potential of NK cells in both primary and metastatic brain malignancies.
In this review, we summarize the role of NK cells in the pathogenesis of tumors in the brain and discuss the avenues investigated to harness their anticancer effects against primary and metastatic CNS tumors, including sources of therapeutic NK cells, combinations with other treatments, and novel engineering approaches for augmenting their cytotoxicity.
We also highlight relevant preclinical evidence and clinical trials of NK cell-based therapies.
论文信息
- 作者
- Balatsoukas A、Rossignoli F、Shah K
- 第一作者单位
- Center for Stem Cell and Translational Immunotherapy (CSTI), Harvard Medical School, Boston, MA 02115, USA.United States
- 通讯作者单位
- Center for Stem Cell and Translational Immunotherapy (CSTI), Harvard Medical School, Boston, MA 02115, USA; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address: kshah@bwh.harvard.edu.United States
- 文献类型
- 美国 NIH 资助研究 · 综述
- 期刊
- Trends in molecular medicine2022 Mar
- 原文标识
- PubMed 35078713 · DOI 10.1016/j.molmed.2021.12.008
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