RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
肿瘤外泌体与 NK 细胞功能障碍：生物学作用、临床意义及免疫治疗启示
英文原题：Cancer exosomes and natural killer cells dysfunction: biological roles, clinical significance and implications for immunotherapy.
查看英文原题
Cancer exosomes and natural killer cells dysfunction: biological roles, clinical significance and implications for immunotherapy.
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中文摘要
肿瘤来源外泌体（TDE）在癌症生物学多个方面发挥关键作用。目前已有明确证据表明，TDE还会损害抗肿瘤免疫，从而促进肿瘤生长。自然杀伤（NK）细胞是免疫监视系统的重要哨兵，可在早期识别恶性细胞，并无需额外活化即可遏制肿瘤发展和转移。基于这一特点，体外扩增NK细胞或NK细胞系（如NK-92细胞）的过继转移受到广泛关注，并被深入研究为有前景的癌症免疫疗法。然而，癌细胞能够利用多种策略（包括分泌外泌体）逃避NK细胞应答。本文综述TDE在癌症诱导NK细胞功能受损中的作用及其机制，并讨论其临床意义，以及癌症免疫治疗中抵消TDE对NK细胞影响的潜在方法。
展开英文摘要原文
Tumor-derived exosomes (TDEs) play pivotal roles in several aspects of cancer biology. It is now evident that TDEs also favor tumor growth by negatively affecting anti-tumor immunity. As important sentinels of immune surveillance system, natural killer (NK) cells can recognize malignant cells very early and counteract the tumor development and metastasis without a need for additional activation.
Based on this rationale, adoptive transfer of ex vivo expanded NK cells/NK cell lines, such as NK-92 cells, has attracted great attention and is widely studied as a promising immunotherapy for cancer treatment.
However, by exploiting various strategies, including secretion of exosomes, cancer cells are able to subvert NK cell responses. This paper reviews the roles of TDEs in cancer-induced NK cells impairments with mechanistic insights. The clinical significance and potential approaches to nullify the effects of TDEs on NK cells in cancer immunotherapy are also discussed.
论文信息
- 作者
- Hosseini R、Sarvnaz H、Arabpour M、Ramshe SM、Asef-Kabiri L、Yousefi H、Akbari ME、Eskandari N
- 第一作者单位
- Department of Immunology School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. reza.hosseini6970@yahoo.com.Iran
- 通讯作者单位
- Surgical Oncologist Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. dr_leili_asef@yahoo.com.Iran
- 文献类型
- 非美国政府资助研究 · 综述
- 期刊
- Molecular cancer2022 Jan 14
- 原文标识
- PubMed 35031075 · DOI 10.1186/s12943-021-01492-7
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