CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题：Fine-tuning CARs for best performance.
Fine-tuning CARs for best performance.
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嵌合抗原受体（CAR）可使T细胞靶向任何表面抗原。然而，CAR需要优化才能对低密度抗原产生活性。Heitzeneder等人对CAR组分进行了迭代调整，最终设计出靶向脑聚糖（GPC2）的CAR，在神经母细胞瘤模型中显示出强效的临床前活性。
Chimeric antigen receptors (CARs) allow redirection of T cells against any surface antigen. However, CARs require optimization to achieve activity against low-density antigens. Heitzeneder et al. perform an iterative adjustment of CAR components to reach a design for targeting cerebroglycan (GPC2) that shows potent pre-clinical activity in neuroblastoma models.
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