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利用合成 T 细胞生物学靶向 AML 而不产生靶向/脱靶毒性

英文原题:Employing Synthetic T-cell Biology to Target AML without On-Target/Off-Cancer Toxicity.

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Employing Synthetic T-cell Biology to Target AML without On-Target/Off-Cancer Toxicity.

PubMed 2021/09/20(内容时间) Blood Cancer Discov Q1 · IF 12.2(JCR 2025)

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中文摘要

急性髓系白血病(AML)的CAR-T 细胞治疗的理想靶点仍难以确定。在本期《Blood Cancer Discovery》中,Richards及其同事探索了CD93作为潜在AML靶抗原的可能性,并设计了一种减轻“靶向/脱癌毒性”的方法。参见Richards等人的相关文章,第648页。

展开英文摘要原文

Ideal targets for chimeric antigen receptor T-cell therapy for acute myeloid leukemia (AML) remain elusive. In this issue of Blood Cancer Discovery , Richards and colleagues explore CD93 as a potential AML target antigen, and devise an approach to mitigate "on-target/off-cancer toxicity." See related article by Richards et al., p. 648 .

论文信息

作者
Velasquez MP、Gottschalk S
第一作者单位
Department of Bone Marrow Transplant and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, Tennessee.United States
通讯作者单位
Department of Bone Marrow Transplant and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, Tennessee. stephen.gottschalk@stjude.org.United States
文献类型
评论
期刊
Blood cancer discovery2021 Nov
原文标识
PubMed 35015677 · DOI 10.1158/2643-3230.BCD-21-0127