免疫检查点阻断通过扩增效应 CD8⁺ T 细胞克隆增强淋巴细胞清除性化疗诱导的抗肿瘤免疫
Immune Checkpoint Blockade Augments Lymphodepleting Chemotherapy-Induced Antitumor Immunity by Expanding Effector CD8+ T-cell Clones.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
用于转化和临床应用的 TIL（肿瘤浸润淋巴细胞）分离与维持：已建立的方法与新进展
英文原题：Isolation and Maintenance of Tumor-Infiltrating Lymphocytes for Translational and Clinical Applications: Established Methods and New Developments.
查看英文原题
Isolation and Maintenance of Tumor-Infiltrating Lymphocytes for Translational and Clinical Applications: Established Methods and New Developments.
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中文摘要
过继性细胞转移（ACT）使用体外扩增的TIL（肿瘤浸润淋巴细胞）治疗晚期转移性黑色素瘤患者，仍然是最有益的疗法之一，能够引发持久缓解。用于扩增 TIL 的方法和方案随着时间的推移而演变，利用不同的培养装置和其他工具，以简化和最大化最终产品的数量和质量。本章总结了 MDACC 的 TIL 项目中使用的最新方案。
展开英文摘要原文
Adoptive cell transfer (ACT) of in vitro expanded tumor-infiltrating lymphocytes (TIL) for the treatment of patients with advanced stages of metastatic melanoma remains one of the most beneficial therapies eliciting long-lasting responses. Methods and protocols used to expand TIL have evolved over time, utilizing different culture devices and other tools, to streamline and maximize the end product in both numbers and quality. Summarized in this chapter are the latest protocols used in the TIL program at MDACC.
论文信息
- 作者
- Fulbright OJ、Forget MA、Haymaker C、Bernatchez C
- 第一作者单位
- Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center (MDACC), Houston, TX, USA.United States
- 通讯作者单位
- Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center (MDACC), Houston, TX, USA. cbernatchez@mdanderson.org.United States
- 期刊
- Methods in molecular biology (Clifton, N.J.)2022
- 原文标识
- PubMed 34993939 · DOI 10.1007/978-1-0716-2014-4_5