CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
CAR-T 细胞免疫治疗：抗击血液系统 B 细胞恶性肿瘤的有力武器
英文原题：CAR T-cell immunotherapy: a powerful weapon for fighting hematological B-cell malignancies.
查看英文原题
CAR T-cell immunotherapy: a powerful weapon for fighting hematological B-cell malignancies.
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中文摘要
当前血液系统恶性肿瘤的标准治疗已为患者带来了显著的临床获益。然而，重要瓶颈仍限制着当前医疗实践所能达到的最佳疗效。疾病的遗传复杂性和肿瘤克隆的异质性使得大多数血液系统疾病难以通过常规治疗确保长期疗效。因此，需要新的治疗策略来改善临床结局。CAR-T 细胞免疫治疗为血液系统恶性肿瘤的靶向治疗开辟了新路径。在本综述中，我们通过一个代表性病例研究，总结了当前CAR-T 细胞治疗的经验、常见副作用的管理、治疗耐药的机制以及提高CAR-T 细胞治疗疗效的新策略。
展开英文摘要原文
The current standard of care in hematological malignancies has brought considerable clinical benefits to patients.
However, important bottlenecks still limit optimal achievements following a current medical practice. The genetic complexity of the diseases and the heterogeneity of tumor clones cause difficulty in ensuring long-term efficacy of conventional treatments for most hematological disorders. Consequently, new treatment strategies are necessary to improve clinical outcomes.
Chimeric antigen receptor T-cell (CAR T) immunotherapy opens a new path for targeted therapy of hematological malignancies. In this review, through a representative case study, we summarize the current experience of CAR T-cell therapy, the management of common side effects, the causative mechanisms of therapy resistance, and new strategies to improve the efficacy of CAR T-cell therapy.
论文信息
- 作者
- Mi JQ、Xu J、Zhou J、Zhao W、Chen Z、Melenhorst JJ、Chen S
- 第一作者单位
- State Key Laboratory of Medical Genomics, Shanghai Institute of Haematology, National Research Centre for Translational Medicine, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.China
- 通讯作者单位
- State Key Laboratory of Medical Genomics, Shanghai Institute of Haematology, National Research Centre for Translational Medicine, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. sjchen@stn.sh.cn.China
- 文献类型
- 综述
- 期刊
- Frontiers of medicine2021 Dec
- 原文标识
- PubMed 34921673 · DOI 10.1007/s11684-021-0904-z