CD81 通过阻断 CD274/PD-L1 的选择性自噬降解驱动放射抵抗性胶质母细胞瘤的免疫逃逸
CD81 drives immune evasion in radioresistant glioblastoma by blocking selective autophagic degradation of CD274/PD-L1.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
脑转移中肿瘤和水肿体积与 TIL（肿瘤浸润淋巴细胞）的关联——一项初步研究
英文原题：Associations between tumor and edema volumes with tumor infiltrating lymphocytes in brain metastasis - A preliminary study.
查看英文原题
Associations between tumor and edema volumes with tumor infiltrating lymphocytes in brain metastasis - A preliminary study.
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研究概要
本研究发现了表达 CD45 的 TIL 与 BM 体积之间的相关性。BM 的肿瘤生长可能导致 TIL 的募集，这可通过 MRI 进行评估。
研究思路结论见上方概要
目的
脑肿瘤的瘤周水肿与生存期和神经系统症状相关。本研究旨在阐明脑转移瘤中水肿体积与TIL（肿瘤浸润淋巴细胞）之间的关联。
方法
25例脑转移患者被纳入这项回顾性研究。通过白细胞共同抗原染色分析表达CD45的TILs。使用MRI半自动估计肿瘤和水肿体积。
结果
肿瘤体积与水肿体积之间未发现相关性。肿瘤体积与基质区表达 CD45 的 TILs 之间呈正相关（r = 0.46，p = 0.02）。表达 CD45 的 TILs 与水肿体积之间未发现相关性。
展开英文摘要原文
OBJECTIVE
Perifocal edema of brain tumors is associated with survival and neurological symptoms. The present study sought to elucidate the association between edema volume and tumor infiltrating lymphocytes (TIL) in brain metastasis.
METHODS
25 patients with brain metastasis were included into the retrospective study. TILs expressing CD45 was analyzed with leucocyte common antigen staining. MRI was used to semiautomatically estimate tumor and edema volumes.
RESULTS
No correlation between tumor volume and edema volume was identified. A positive correlation was identified between tumor volume and TILs expressing CD45 of the stromal compartment (r = 0.46, p = 0.02). No correlations were identified between TILs expressing CD45 and edema volume.
CONCLUSIONS
The present study identified correlations between TILs expressing CD45 and volume of BM. The tumor growth of BM might lead to a recruitment of TIL, which could be assessed by MRI.
论文信息
- 作者
- Meyer HJ、Höhn AK、Prasse G、Hoffmann KT、Surov A
- 单位
- Department of Diagnostic and Interventional Radiology, University of Leipzig, Leipzig, Germany. Electronic address: Hans-jonas.meyer@medizin.uni-leipzig.de.Germany
- 期刊
- Clinical neurology and neurosurgery2022 Jan
- 原文标识
- PubMed 34915356 · DOI 10.1016/j.clineuro.2021.107088