CD81 通过阻断 CD274/PD-L1 的选择性自噬降解驱动放射抵抗性胶质母细胞瘤的免疫逃逸
CD81 drives immune evasion in radioresistant glioblastoma by blocking selective autophagic degradation of CD274/PD-L1.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
CCNB2 是低级别胶质瘤的一种新型预后因素和潜在治疗靶点
英文原题：CCNB2 is a novel prognostic factor and a potential therapeutic target in low-grade glioma.
查看英文原题
CCNB2 is a novel prognostic factor and a potential therapeutic target in low-grade glioma.
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研究概要
CCNB2 可能作为判断 LGG 预后的潜在生物标志物，并且也与免疫浸润相关。
研究思路结论见上方概要
背景
细胞周期蛋白B2（CCNB2）是细胞周期蛋白通路的重要组成部分，在癌症的发生和发展中起关键作用。然而，低级别胶质瘤（LGG）的预后、CCNB2与TIL（肿瘤浸润淋巴细胞）之间的相关性尚不清楚。
方法
通过GEPIA2和TIMER数据库查询CCNB2在LGG中的表达。利用CGGA数据库分析CCNB2与LGG临床病理特征之间的关系。通过GEPIA2评估CCNB2表达与OS之间的关系。通过TIMER数据库分析CCNB2与LGG免疫浸润的相关性。最后，采用qRT-PCR检测CCNB2的表达。
结果
CCNB2在不同肿瘤组织中的表达存在差异，但在LGG中高于正常组织。CCNB2高表达的LGG患者预后较差。CCNB2的表达与年龄、WHO分级、IDH突变状态、1p/19q共缺失状态及其他临床病理特征相关。CCNB2在LGG中的表达与B细胞、树突状细胞和巨噬细胞的浸润水平呈正相关。qRT-PCR结果显示，CCNB2在LGG组织中的表达高于正常组织，且CCNB2高表达与更差的预后相关。
展开英文摘要原文
BACKGROUND
Cyclin B2 (CCNB2) is an important component of the cyclin pathway and plays a key role in the occurrence and development of cancer. However, the correlation between prognosis of low-grade glioma (LGG), CCNB2, and tumor infiltrating lymphocytes is not clear.
METHODS
The expression of CCNB2 in LGG was queried in Gene Expression Profiling Interactive Analysis 2 (GEPIA2) and TIMER databases. The relationships between CCNB2 and the clinicopathological features of LGG were analyzed using the Chinese Glioma Genome Atlas (CGGA) database. The relationship between CCNB2 expression and overall survival (OS) was evaluated by GEPIA2. The correlation between CCNB2 and LGG immune infiltration was analyzed by the TIMER database. Finally, quantitative real-time polymerase chain reaction (qRT-PCR) was performed to detect CCNB2 expression.
RESULTS
The expression of CCNB2 differed across different tumor tissues, but was higher in LGG than in normal tissues. LGG patients with high expression of CCNB2 have poorer prognosis. The expression of CCNB2 was correlated with age, WHO grade, IDH mutational status, 1p/19q codeletion status, and other clinicopathological features. The expression of CCNB2 in LGG was positively correlated with the infiltration level of B cells, dendritic cells, and macrophages. qRT-PCR results revealed that the expression of CCNB2 in LGG tissues was higher than normal tissues and higher expression of CCNB2 was associated with worse prognosis.
CONCLUSION
CCNB2 may be used as a potential biomarker to determine the prognosis of LGG and is also related to immune infiltration.
论文信息
- 作者
- Wang D、Sun H、Li X、Wang G、Yan G、Ren H、Hou B
- 单位
- Department of Neurosurgery, Lanzhou University Second Hospital, Lanzhou, Gansu 730030, P.R. China.China
- 文献类型
- 非美国政府资助研究
- 期刊
- Bioscience reports2022 Jan 28
- 原文标识
- PubMed 34908101 · DOI 10.1042/BSR20211939
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