RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
扩增 NK 细胞疗法成功治疗冒烟型人类 T 细胞白血病病毒 1 型相关细支气管炎与肺泡异常
英文原题：Successful treatment of smouldering Human T cell Leukemia Virus Type1 associated bronchiolitis and alveolar abnormalities with amplified natural killer therapy.
查看英文原题
Successful treatment of smouldering Human T cell Leukemia Virus Type1 associated bronchiolitis and alveolar abnormalities with amplified natural killer therapy.
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中文摘要
在扩增自然杀伤（ANK）细胞免疫治疗中，从患者血液中提取NK细胞，培养以增强其抗癌效果并扩增后再回输体内。在此，我们对一名81岁女性患者实施了ANK治疗，该患者被诊断为冒烟型人类T细胞白血病病毒相关细支气管肺泡障碍。在每周两次、共八次NK细胞输注后，CT扫描上的双侧弥漫性颗粒状阴影及整体呼吸功能显著改善。随后，患者接受门诊治疗，未出现严重副作用。因此，由于副作用少见，ANK治疗对老年患者可能是安全的。
展开英文摘要原文
In amplified natural killer (ANK) cell immunotherapy, NK cells are extracted from the patient's blood, cultured for enhancing its anticancer effects and amplified before they are returned to the body.
Here, we administered ANK therapy to an 81-year-old female patient diagnosed with smouldering human T cell leukaemia virus-associated bronchioloalveolar disorder. After eight sessions of twice-weekly NK cell infusion, the bilateral diffuse granular shadows on a CT scan and the overall respiratory function improved markedly. Later, the patient received outpatient treatment without serious side effects.
Thus, ANK therapy may be safe for elderly patients owing to its infrequent side effects.
论文信息
- 作者
- Nagai K、Nagai S、Hara Y
- 单位
- Ebino Centro Clinic, Ebino City, Miyazaki, Japan ken701n427@gmail.com.Japan
- 文献类型
- 病例报告
- 期刊
- BMJ case reports2021 Dec 7
- 原文标识
- PubMed 34876443 · DOI 10.1136/bcr-2021-244619
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