淋巴细胞清除前绝对淋巴细胞计数影响接受 CAR-T 细胞治疗的多发性骨髓瘤患者的结局

Chimeric antigen receptor (CAR) T cell therapy has shown unprecedented response rates in patients with relapsed/refractory (R/R) multiple myeloma (MM).

However, the factors associated with immediate response and durable remission have not been fully elucidated.

This study aimed to investigate the impact of prelymphodepletion (pre-LD) absolute lymphocyte count (ALC) on the outcomes of CAR T cell therapy and cytokine release syndrome (CRS). A receiver operating characteristic curve was used to determine the optimal cutoff value of pre-LD ALC. The correlation of pre-LD ALC with deep response (defined as very good partial response or better), CRS, and long-term outcomes was analyzed in 85 patients with R/R MM who received CAR T cell treatment. The median pre-LD ALC was 1. 0 10 9 /L (range, 0. 1 to 2. 9 10 9 /L). The optimal cutoff value of pre-LD ALC was 0. 75 10 9 /L.

Twenty-two patients (26%) had a low pre-LD ALC (<0. 75 10 9 /L), and 63 patients (74%) had a high pre-LD ALC ( 0. 75 10 9 /L). The deep response rate was significantly higher in patients with a high pre-LD ALC compared with patients with a low pre-LD ALC (76% versus 41%; P = . 002).

Patients with a low pre-LD ALC had significantly inferior overall survival (OS) and progression-free survival (PFS) compared with those with a high pre-LD ALC (median OS, 15. 4 months versus not reached [P < . 001]; median PFS, 8. 4 months versus 27. 3 months [P < . 001]). No correlation between pre-LD ALC and CRS was observed.

Our data indicate that pre-LD ALC may be a useful indicator to predict the outcomes of CAR T cell therapy in patients with R/R MM. 2021 American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc.