CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
肿瘤治疗的神经系统并发症
英文原题：Neurologic Complications of Cancer Therapies.
查看英文原题
Neurologic Complications of Cancer Therapies.
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研究思路按摘要原文分段
目的
综述系统性抗癌治疗和放射治疗的神经系统并发症。
结果
尽管许多较新的全身性治疗比传统细胞毒性化疗具有更有利的副作用特征，但在一些较新的靶向治疗、免疫治疗和T细胞衔接治疗（包括CAR-T 治疗）中已观察到神经毒性。放射诱导神经毒性的最新进展主要集中在认知功能障碍的预防和管理上，这是脑部放疗已知的长期并发症。癌症治疗可损伤中枢和周围神经系统，且损伤并不总是可逆的。神经科医生和肿瘤科医生必须了解与较新治疗相关的神经毒性，尤其是CAR-T 治疗和免疫治疗。早期识别和适当管理有助于尽量减少神经损伤。
展开英文摘要原文
PURPOSE OF REVIEW: To review the neurologic complications of systemic anti-cancer therapies and radiation therapy. RECENT FINDINGS: Although many of the newer systemic therapies have more favorable side effect profiles than traditional cytotoxic chemotherapy, neurotoxicity has been seen with some of newer targeted therapies, immunotherapy, and T cell engaging therapies, including CAR-T therapy.
The most recent advances in radiation-induced neurotoxicity have focused on the prevention and the management of cognitive dysfunction, a known long-term complication of brain irradiation. Cancer therapies can damage both the central and the peripheral nervous systems, and the damage may not always be reversible. Neurologists and oncologists must be aware of the neurotoxicities associated with newer treatments, particularly CAR-T therapy and immunotherapy. Early recognition and appropriate management can help minimize neurologic injury.
论文信息
- 作者
- Lee EQ
- 单位
- Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, 450 Brookline Avenue, Boston, MA, 02215, USA. eqlee@partners.org.United States
- 文献类型
- 综述
- 期刊
- Current neurology and neuroscience reports2021 Nov 24
- 原文标识
- PubMed 34817688 · DOI 10.1007/s11910-021-01151-w