RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
旧法新招：释放 NK 细胞对抗转移的力量
英文原题：Something Old and Something New to Unleash the Power of Natural Killer Cells against Metastases.
查看英文原题
Something Old and Something New to Unleash the Power of Natural Killer Cells against Metastases.
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中文摘要
单药免疫治疗改善了癌症患者的结局，但仅少数患者有应答，因此需要研究免疫治疗药物的联合方案。在本期 Cancer Immunology Research 中，Milling 及其同事表明，在三阴性乳腺癌小鼠模型中，新辅助治疗采用瘤内干扰素基因刺激因子激动剂联合全身 IL2 和抗 PD-1 可使肺转移被NK 细胞清除。参见 Milling 等人的相关文章，第 26 页。(4)。
展开英文摘要原文
Single-agent immunotherapy has improved outcomes for patients with cancer, but only a minority of patients respond, necessitating investigation of combinations of immunotherapy agents. In this issue of Cancer Immunology Research , Milling and colleagues show that neoadjuvant therapy with an intratumoral stimulator of interferon genes agonist combined with systemic IL2 and anti-PD-1 results in clearance of lung metastases mediated by natural killer cells in mouse models of triple-negative breast cancer. See related article by Milling et al., p. 26. (4).
论文信息
- 作者
- Demaria S
- 单位
- Weill Cornell Medicine, New York, New York. szd3005@med.cornell.edu.United States
- 文献类型
- 评论
- 期刊
- Cancer immunology research2022 Jan
- 原文标识
- PubMed 34815266 · DOI 10.1158/2326-6066.CIR-21-0948