CELL INTELLIGENCE · 肿瘤细胞治疗研究

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头颈部鳞状细胞癌中动态对比增强 MRI 与 TIL（肿瘤浸润淋巴细胞）及肿瘤-间质比的相关性

英文原题：Associations between dynamic-contrast enhanced MRI and tumor infiltrating lymphocytes and tumor-stroma ratio in head and neck squamous cell cancer.

查看英文原题

Associations between dynamic-contrast enhanced MRI and tumor infiltrating lymphocytes and tumor-stroma ratio in head and neck squamous cell cancer.

PubMed 2021/11/20（内容时间） Cancer Imaging Q1 · IF 4.8（JCR 2025）

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头颈部鳞癌地区：欧洲
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研究概要

DCE-MRI 可能能够反映 HNSCC 中的肿瘤分区和 TIL 表达。最有前景的参数是源自 K trans 和 V e 的值。

研究思路结论见上方概要

目的

本研究采用动态对比增强MRI（DCE-MRI）来阐明其与头颈部鳞状细胞癌（HNSCC）中TIL（肿瘤浸润淋巴细胞）、间质比例及波形蛋白表达之间可能存在的关联。

方法

总体而言，本研究纳入了26例不同原发部位的HNSCC患者。DCE-MRI在3 T MRI上获取，并采用直方图方法进行全病灶测量分析。TIL和vimentin表达在任何形式治疗前通过活检样本计算。P16染色用于确定HPV状态。

结果

肿瘤-间质比与源自K trans的熵相关（r = - 0.52，p = 0.0071），并与源自V e的峰度相关（r = - 0.53，p = 0.0058）。若干源自V e的参数与间质区室中TIL的表达相关。肿瘤区室中的TIL与源自K trans的熵相关（r = 0.39，p = 0.047）、与源自V e的p90相关（r = 0.41，p = 0.036），并与源自V e的偏度相关（r = 0.41，p = 0.037）。此外，这些关联在HPV阳性和阴性肿瘤之间有所不同。

展开英文摘要原文
OBJECTIVES

The present study used dynamic-contrast enhanced MRI (DCE-MRI) to elucidate possible associations with tumor-infiltrating lymphocytes (TIL), stroma ratio and vimentin expression in head and neck squamous cell cancer (HNSCC).

METHODS

Overall, 26 patients with primary HNSCC of different localizations were involved in the study. DCE-MRI was obtained on a 3 T MRI and analyzed with a whole lesion measurement using a histogram approach. TIL- and vimentin-expression was calculated on bioptic samples before any form of treatment. P16 staining was used to define HPV-status.

RESULTS

Tumor-stroma ratio correlated with entropy derived from K trans (r = - 0.52, p = 0.0071) and with kurtosis derived from V e (r = - 0.53, p = 0.0058). Several V e derived parameters correlated with expression of TIL within the stroma compartment. TIL within the tumor compartment correlated with entropy derived from K trans (r = 0.39, p = 0.047), p90 derived from V e (r = 0.41, p = 0.036) and skewness derived from V e (r = 0.41, p = 0.037). Furthermore, these associations were different between HPV positive and negative tumors.

CONCLUSIONS

DCE-MRI might be able to reflect tumor compartments and TIL expression in HNSCC. The most promising parameters were values derived from K trans and V e .

论文信息

作者
Meyer HJ、Höhn AK、Surov A
单位
Department of Diagnostic and Interventional Radiology, University of Leipzig, Leipzig, Germany. Hans-jonas.meyer@medizin.uni-leipzig.de.Germany
期刊
Cancer imaging : the official publication of the International Cancer Imaging Society2021 Nov 20
原文标识
PubMed 34801089　·　DOI 10.1186/s40644-021-00429-z

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