CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
巴西血液学、血液学、血液治疗与细胞治疗协会关于基因修饰细胞的共识。综述文章：实体瘤细胞治疗
英文原题：Associação Brasileira de Hematologia, Hematologia, Hemoterapia e Terapia Celular Consensus on genetically modified cells. Review article: Cell therapy in solid tumors.
查看英文原题
Associação Brasileira de Hematologia, Hematologia, Hemoterapia e Terapia Celular Consensus on genetically modified cells. Review article: Cell therapy in solid tumors.
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中文摘要
过去十年中，癌症治疗应用免疫疗法取得重大进步，检查点抑制剂改善了癌症患者生存。然而，只有一部分实体瘤对这类免疫疗法有应答。另一类免疫疗法是将细胞疗法作为过继治疗方式使用，其中包括CAR-T 细胞、TIL（肿瘤浸润淋巴细胞）和TCR-T细胞等不同形式。这些疗法已证明对血液系统肿瘤有效，也可能惠及对检查点抑制剂无应答的肿瘤患者。本综述旨在阐述实体瘤患者过继细胞疗法的理论依据、作用方式、临床应用及研究结果。
展开英文摘要原文
The use of immunotherapy in cancer treatment over the past decade has resulted in significant advances and improvements in cancer patients survival with the use of checkpoint inhibitors. Nevertheless, only a fraction of solid tumors responds to this immunotherapy modality. Another modality of immunotherapy consists of employing cell-based therapy as an adoptive therapeutic modality.
That involves distinct modalities of cellular therapies such as CAR T cells (chimeric antigen receptor T cell), TILs (tumor-infiltrating lymphocytes), and TCR T cells. Those treatments have proven effective in hematologic tumors and could have an impact in tumors that do not respond to checkpoint inhibitors. This review aims to outline the rationale, operation, clinical applicability, and results of adoptive cell therapy for patients with solid tumors.
论文信息
- 作者
- Nardo M、Motta TC、Colli LM、Avanzi MP
- 第一作者单位
- Clinical Oncology, MD Anderson Cancer Center, Houston, USA.United States
- 通讯作者单位
- Neogene Therapeutics, Santa Monica, USA. Electronic address: mauro.avanzi@yahoo.com.br.United States
- 文献类型
- 综述
- 期刊
- Hematology, transfusion and cell therapy2021 Nov
- 原文标识
- PubMed 34794801 · DOI 10.1016/j.htct.2021.09.011
在 PubMed 查看 → 出版商原文（DOI） 全文 PDF（PMC）· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →