CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
CAR-T 细胞治疗细胞因子释放综合征和神经毒性机制及相关预防与管理策略
英文原题：Mechanisms of cytokine release syndrome and neurotoxicity of CAR T-cell therapy and associated prevention and management strategies.
查看英文原题
Mechanisms of cytokine release syndrome and neurotoxicity of CAR T-cell therapy and associated prevention and management strategies.
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中文摘要
嵌合抗原受体（CAR）T细胞疗法在血液系统恶性肿瘤中取得了令人瞩目的疗效，并改变了治疗格局。迄今为止，已有五种CAR-T 细胞产品获得美国食品药品监督管理局（FDA）批准。然而，一些显著的毒性反应给CAR-T 细胞疗法的发展带来了巨大挑战，其中最突出的是细胞因子释放综合征（CRS）和免疫效应细胞相关神经毒性综合征（ICANS）。了解这些毒性反应的机制并建立预防和治疗策略至关重要。在本综述中，我们总结了CRS和ICANS的机制，并提供了潜在的治疗和预防策略。
展开英文摘要原文
Chimeric antigen receptor (CAR) T-cell therapy has yielded impressive outcomes and transformed treatment algorithms for hematological malignancies. To date, five CAR T-cell products have been approved by the US Food and Drug Administration (FDA). Nevertheless, some significant toxicities pose great challenges to the development of CAR T-cell therapy, most notably cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS).
Understanding the mechanisms underlying these toxicities and establishing prevention and treatment strategies are important. In this review, we summarize the mechanisms underlying CRS and ICANS and provide potential treatment and prevention strategies.
论文信息
- 作者
- Xiao X、Huang S、Chen S、Wang Y、Sun Q、Xu X、Li Y
- 第一作者单位
- The Second School of Clinical Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, People's Republic of China.China
- 通讯作者单位
- Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, People's Republic of China. liyuhua2011gz@163.com.China
- 文献类型
- 综述
- 期刊
- Journal of experimental & clinical cancer research : CR2021 Nov 18
- 原文标识
- PubMed 34794490 · DOI 10.1186/s13046-021-02148-6
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